SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4plj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		3 / 3 ALA A 507
VAL A 503
TRP A 472
 None
 0.90A 1gmkA-4pljA:
undetectable
1gmkB-4pljA:
undetectable		 1gmkA-4pljA:
16.07
1gmkB-4pljA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		3 / 3 ALA A 507
VAL A 503
TRP A 472
 None
 0.99A 1gmkC-4pljA:
undetectable
1gmkD-4pljA:
undetectable		 1gmkC-4pljA:
16.07
1gmkD-4pljA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4plj CAPSID PROTEIN
8G12 HEAVY CHAIN
(Orthohepevirus
A;
Mus
musculus) 		5 / 9 GLY A 591
GLU A 479
PHE H  62
GLN H  60
ILE H  46
 None
 1.36A 1oltA-4pljA:
undetectable		 1oltA-4pljA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 11 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 0.93A 2ceoA-4pljA:
undetectable		 2ceoA-4pljA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 12 ARG A 460
ALA A 507
PHE A 462
LEU A 471
ASP A 469
 None
 0.99A 2qb4A-4pljA:
undetectable		 2qb4A-4pljA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 11 ARG A 460
ALA A 507
PHE A 462
LEU A 471
ASP A 469
 None
 0.99A 2qjuA-4pljA:
undetectable		 2qjuA-4pljA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 10 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 1.04A 2riwA-4pljA:
0.0
2riwB-4pljA:
undetectable		 2riwA-4pljA:
17.06
2riwB-4pljA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 12 LEU A 471
LEU A 465
VAL A 519
ILE A 571
PHE A 462
 None
 1.20A 2weyA-4pljA:
undetectable		 2weyA-4pljA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 10 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 1.14A 2xn6A-4pljA:
0.0
2xn6B-4pljA:
undetectable		 2xn6A-4pljA:
16.52
2xn6B-4pljA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		5 / 10 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 1.14A 2xn7A-4pljA:
0.0
2xn7B-4pljA:
undetectable		 2xn7A-4pljA:
16.52
2xn7B-4pljA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		4 / 8 HIS A 577
GLY A 576
TRP A 516
PHE A 537
 None
 1.28A 3ccfA-4pljA:
undetectable		 3ccfA-4pljA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		4 / 4 PHE A 547
TYR A 480
VAL A 538
LEU A 539
 None
 1.44A 3keeD-4pljA:
undetectable		 3keeD-4pljA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4plj 8G12 HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER H  74
SER H  75
SER H  76
SER H  23
 None
 1.38A 5hswA-4pljH:
undetectable		 5hswA-4pljH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4plj 8G12 HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H  14
PHE H 156
TYR H 155
LEU H 116
THR H  85
 None
 1.10A 5tl8A-4pljH:
undetectable		 5tl8A-4pljH:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4plj CAPSID PROTEIN
(Orthohepevirus
A) 		4 / 6 ASN A 587
THR A 583
ILE A 595
GLU A 549
 None
 1.16A 5uigA-4pljA:
undetectable		 5uigA-4pljA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4plj 8G12 HEAVY CHAIN
(Mus
musculus) 		4 / 5 GLU H 158
PHE H 156
HIS H 209
THR H 118
 None
 1.15A 6b58A-4pljH:
undetectable		 6b58A-4pljH:
16.81