SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4pls ARM00010
(synthetic
construct) 		5 / 12 ALA A  39
ILE A 111
LEU A  62
LEU A  55
LEU A  32
 None
 1.25A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4pls ARM00010
(synthetic
construct) 		5 / 12 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.16A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4pls ARM00010
(synthetic
construct) 		5 / 12 ALA A 123
ILE A 195
LEU A 146
LEU A 139
LEU A 116
 None
 1.40A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4pls ARM00010
(synthetic
construct) 		5 / 12 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.32A 1eiiA-4plsA:
undetectable		 1eiiA-4plsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pls ARM00010
(synthetic
construct) 		4 / 6 SER A  40
GLU A  72
SER A  30
GLN A  26
 None
 1.09A 2cl5B-4plsA:
undetectable		 2cl5B-4plsA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4pls ARM00010
(synthetic
construct) 		5 / 10 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.12A 2riwA-4plsA:
undetectable
2riwB-4plsA:
undetectable		 2riwA-4plsA:
22.46
2riwB-4plsA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4pls ARM00010
(synthetic
construct) 		5 / 10 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.09A 2xn6A-4plsA:
undetectable
2xn6B-4plsA:
undetectable		 2xn6A-4plsA:
21.69
2xn6B-4plsA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pls ARM00010
(synthetic
construct) 		4 / 6 SER A  40
GLU A  72
SER A  30
GLN A  26
 None
 1.14A 2zvjA-4plsA:
undetectable		 2zvjA-4plsA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4pls ARM00010
(synthetic
construct) 		5 / 12 ALA A 174
GLY A 168
GLY A 167
VAL A 133
ILE A 134
 None
 0.85A 3cyxB-4plsA:
undetectable		 3cyxB-4plsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4pls ARM00010
(synthetic
construct) 		5 / 10 ILE A  46
SER A  63
ALA A  57
LEU A  58
ALA A  73
 None
 1.43A 3lw5B-4plsA:
undetectable		 3lw5B-4plsA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4pls ARM00010
(synthetic
construct) 		4 / 6 LEU A  62
LEU A 100
ILE A 122
TRP A 117
 None
 0.99A 4do3B-4plsA:
undetectable		 4do3B-4plsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4pls ARM00010
(synthetic
construct) 		5 / 12 LEU A 188
GLY A 162
LEU A 161
ALA A 207
VAL A 175
 None
 1.10A 4wnwB-4plsA:
undetectable		 4wnwB-4plsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pls ARM00010
(synthetic
construct) 		4 / 5 SER A  40
GLU A  72
SER A  30
GLN A  26
 None
 1.11A 5fhrB-4plsA:
undetectable		 5fhrB-4plsA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4pls ARM00010
(synthetic
construct) 		4 / 6 ARG A  33
LEU A  35
ALA A  54
GLN A  37
 None
 1.00A 6b89B-4plsA:
undetectable		 6b89B-4plsA:
14.59