SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  16
GLY A 143
ILE A 142
THR A  25
ILE A  27
 None
 0.80A 1c6yA-4pm4A:
undetectable		 1c6yA-4pm4A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 4 VAL A  66
TRP A  58
TRP A  69
 None
 1.16A 1gmkA-4pm4A:
undetectable
1gmkB-4pm4A:
undetectable		 1gmkA-4pm4A:
8.50
1gmkB-4pm4A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 100
GLY A  38
PRO A  52
VAL A  34
 None
 0.88A 2aojA-4pm4A:
undetectable		 2aojA-4pm4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 240
ALA A 281
GLY A 278
THR A  40
PHE A 132
 None
 1.04A 2y7hB-4pm4A:
undetectable		 2y7hB-4pm4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 240
ALA A 281
GLY A 278
THR A  40
PHE A 132
 None
 1.04A 2y7hC-4pm4A:
undetectable		 2y7hC-4pm4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  44
ASP A  43
ASP A 137
ASP A 200
 None
 1.06A 3havA-4pm4A:
undetectable		 3havA-4pm4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  44
ASP A  43
ASP A 200
TRP A 197
 None
 1.23A 3havA-4pm4A:
undetectable		 3havA-4pm4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 232
SER A 212
GLY A 222
ALA A 192
LEU A 181
 None
 1.18A 3n8yA-4pm4A:
undetectable		 3n8yA-4pm4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 116
ALA A 124
THR A 112
PHE A  22
 None
 1.40A 3vasB-4pm4A:
undetectable		 3vasB-4pm4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.40A 4eilA-4pm4A:
2.4		 4eilA-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.44A 4eilB-4pm4A:
undetectable		 4eilB-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.40A 4eilC-4pm4A:
undetectable		 4eilC-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.43A 4eilD-4pm4A:
undetectable		 4eilD-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.41A 4eilE-4pm4A:
undetectable		 4eilE-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 179
ILE A 209
ALA A 195
ALA A 217
ALA A 192
 None
 1.15A 4enhA-4pm4A:
undetectable		 4enhA-4pm4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.47A 4kyaB-4pm4A:
undetectable		 4kyaB-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.46A 4kyaD-4pm4A:
undetectable		 4kyaD-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.47A 4kyaF-4pm4A:
undetectable		 4kyaF-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.45A 4kyaH-4pm4A:
undetectable		 4kyaH-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_2
(SERUM ALBUMIN)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 291
GLU A 275
ASP A  44
LYS A  73
 None
 0.95A 4l9qA-4pm4A:
0.0		 4l9qA-4pm4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  16
GLY A 143
ILE A 142
THR A  25
ILE A  27
 None
 0.85A 4njuB-4pm4A:
undetectable		 4njuB-4pm4A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  16
GLY A 143
ILE A 142
THR A  25
ILE A  27
 None
 0.85A 4njuD-4pm4A:
undetectable		 4njuD-4pm4A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  16
GLY A 143
ILE A 142
THR A  25
ILE A  27
 None
 0.83A 4njvB-4pm4A:
undetectable		 4njvB-4pm4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		6 / 12 TRP A 135
PHE A 201
ILE A 240
LEU A 295
PRO A 296
ILE A 280
 None
 1.29A 4p3qA-4pm4A:
undetectable		 4p3qA-4pm4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 224
ALA A 192
ALA A 236
LEU A 233
PHE A 216
 None
None
None
None
SO4  A 401 (-4.9A)
 1.46A 4zo1X-4pm4A:
undetectable		 4zo1X-4pm4A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 THR A  56
ASP A  57
LEU A  84
ASP A  85
 None
 1.11A 5tdzA-4pm4A:
undetectable		 5tdzA-4pm4A:
21.33