SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pmd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		5 / 12 ALA A 107
ASP A 102
GLU A 106
ARG A 156
ILE A 165
 None
 1.14A 1errA-4pmdA:
undetectable		 1errA-4pmdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 6 ASN A 182
ARG A  85
ILE A 214
GLY A 213
 None
 0.99A 1oniA-4pmdA:
undetectable
1oniB-4pmdA:
0.8		 1oniA-4pmdA:
18.08
1oniB-4pmdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		5 / 11 SER A 293
LEU A 296
ALA A  26
SER A  46
THR A  48
 None
 1.15A 1tz8A-4pmdA:
undetectable
1tz8B-4pmdA:
undetectable		 1tz8A-4pmdA:
14.03
1tz8B-4pmdA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 6 LEU A  89
LEU A 116
PRO A  96
VAL A  99
 None
 1.19A 2dqyC-4pmdA:
undetectable		 2dqyC-4pmdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 6 ASN A 182
HIS A  87
GLN A 244
THR A  48
 None
BXP  A 401 (-3.9A)
None
None
 1.18A 2hkkA-4pmdA:
undetectable		 2hkkA-4pmdA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 6 ALA A 107
ASP A 102
GLU A 106
ARG A 156
 None
 1.11A 2ouzA-4pmdA:
undetectable		 2ouzA-4pmdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 4 ILE A 233
ARG A  85
ILE A 291
THR A 235
 None
 1.21A 3ia4C-4pmdA:
undetectable		 3ia4C-4pmdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		3 / 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.73A 3jayA-4pmdA:
undetectable		 3jayA-4pmdA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		3 / 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.67A 3jb2A-4pmdA:
undetectable		 3jb2A-4pmdA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		3 / 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.62A 3jb3A-4pmdA:
undetectable		 3jb3A-4pmdA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		5 / 12 ILE A 323
ILE A 334
ILE A 335
PHE A 321
HIS A  43
 None
 1.49A 3phaB-4pmdA:
2.6		 3phaB-4pmdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		5 / 12 PHE A  67
VAL A 130
ILE A  58
MET A  53
HIS A 119
 None
 1.22A 3sp6A-4pmdA:
undetectable		 3sp6A-4pmdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		5 / 12 GLN A 215
ASP A 135
PHE A 180
SER A 133
GLU A  50
 BXP  A 401 (-2.7A)
None
None
None
BXP  A 401 (-3.6A)
 1.17A 3t7sA-4pmdA:
undetectable		 3t7sA-4pmdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 7 VAL A 294
LEU A 248
LEU A 296
ILE A 334
 None
 0.98A 3u5kB-4pmdA:
undetectable		 3u5kB-4pmdA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		3 / 3 PHE A 100
ASP A 102
ARG A 115
 None
 0.78A 4eahF-4pmdA:
undetectable		 4eahF-4pmdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		3 / 3 PHE A 100
ASP A 102
ARG A 115
 None
 0.77A 4eahG-4pmdA:
1.4		 4eahG-4pmdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		3 / 4 SER A  46
GLY A 213
GLU A 187
 None
 0.60A 4juoA-4pmdA:
undetectable
4juoC-4pmdA:
undetectable		 4juoA-4pmdA:
21.72
4juoC-4pmdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4pmd ENDO-1,4-BETA-XYLANA
SE
(Caldicellulosiru
ptor
bescii) 		4 / 7 ILE A  39
LEU A  13
ALA A  25
ILE A 299
 None
 0.77A 4y03A-4pmdA:
undetectable		 4y03A-4pmdA:
17.94