SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 LEU A 228
ALA A 252
ASP A 251
ASP A 254
PHE A 227
 None
 1.25A 1d4sA-4pmjA:
undetectable		 1d4sA-4pmjA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 PHE A 146
ALA A  88
GLY A 118
THR A  93
LEU A 154
 None
 1.08A 2hw2A-4pmjA:
undetectable		 2hw2A-4pmjA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 4 LEU A 262
THR A 259
ILE A 255
HIS A 216
 None
 1.41A 2jfaB-4pmjA:
undetectable		 2jfaB-4pmjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 7 ALA A  54
TYR A  57
MET A 193
HIS A 115
 None
None
None
NAP  A 301 (-4.4A)
 1.08A 2pncA-4pmjA:
undetectable		 2pncA-4pmjA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  40
LEU A  44
GLY A  43
MET A  26
THR A 240
 None
None
None
None
NAP  A 301 (-3.7A)
 1.45A 2q7lA-4pmjA:
undetectable		 2q7lA-4pmjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ILE A  51
THR A  53
VAL A  66
ILE A  65
SER A  39
 None
 1.40A 3kpbD-4pmjA:
undetectable		 3kpbD-4pmjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 TYR A  57
HIS A 115
ASN A 145
TYR A 195
SER A 196
 None
NAP  A 301 (-4.4A)
NAP  A 301 (-3.4A)
NAP  A 301 (-3.2A)
NAP  A 301 (-2.7A)
 0.37A 3ug8A-4pmjA:
31.2		 3ug8A-4pmjA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 PRO A 238
SER A 236
GLY A  43
MET A  48
 NAP  A 301 (-4.7A)
None
None
None
 0.72A 4klrB-4pmjA:
undetectable		 4klrB-4pmjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 6 GLU A 178
ASP A 180
ASP A 147
ASN A 166
 None
 1.32A 4ntxA-4pmjA:
undetectable
4ntxC-4pmjA:
undetectable		 4ntxA-4pmjA:
21.86
4ntxC-4pmjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A 111
ASN A 166
ALA A 165
VAL A 190
 None
 0.74A 4zbqA-4pmjA:
undetectable		 4zbqA-4pmjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  20
VAL A 163
THR A  49
GLN A  21
LEU A  19
 None
 1.05A 5hg0A-4pmjA:
undetectable		 5hg0A-4pmjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4pmj PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  20
VAL A 163
THR A  49
GLN A  21
LEU A  19
 None
 1.06A 5hg0B-4pmjA:
undetectable		 5hg0B-4pmjA:
20.60