SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4pmr TAT-SECRETED PROTEIN
RV2525C
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  68
GLY A  78
ASP A  43
TYR A  65
 None
 0.88A 2aouA-4pmrA:
undetectable		 2aouA-4pmrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4pmr TAT-SECRETED PROTEIN
RV2525C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  97
LEU A  89
VAL A 224
ILE A 231
VAL A 221
 None
 0.98A 3w68D-4pmrA:
undetectable		 3w68D-4pmrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4pmr TAT-SECRETED PROTEIN
RV2525C
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 None
None
EPE  A 301 (-2.8A)
None
 1.05A 4z4fA-4pmrA:
2.4		 4z4fA-4pmrA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4pmr TAT-SECRETED PROTEIN
RV2525C
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 None
None
EPE  A 301 (-2.8A)
None
 1.01A 4z4gA-4pmrA:
2.3		 4z4gA-4pmrA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4pmr TAT-SECRETED PROTEIN
RV2525C
(Mycobacterium
tuberculosis) 		5 / 9 HIS A 120
GLY A 112
SER A 142
LEU A 160
ARG A 161
 None
NA  A 302 (-3.8A)
None
None
None
 1.37A 5o96E-4pmrA:
undetectable
5o96F-4pmrA:
undetectable		 5o96E-4pmrA:
20.99
5o96F-4pmrA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4pmr TAT-SECRETED PROTEIN
RV2525C
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 127
TYR A  65
LYS A  79
PRO A  80
 None
None
EPE  A 301 (-2.8A)
None
 1.08A 5t7bA-4pmrA:
undetectable		 5t7bA-4pmrA:
12.53