SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 PHE A 294
LEU A 317
SER A 320
 None
 0.89A 1e7aA-4pmwA:
undetectable		 1e7aA-4pmwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 9 ALA A 231
ILE A  85
VAL A 111
PRO A  88
ILE A  94
 None
 0.95A 1hshB-4pmwA:
undetectable		 1hshB-4pmwA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 9 PHE A 479
ARG A 481
ALA A 714
LEU A 717
GLY A 480
 None
 1.19A 1jb0A-4pmwA:
undetectable		 1jb0A-4pmwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 ALA A 393
VAL A 406
TRP A 466
 None
 0.90A 1micA-4pmwA:
undetectable
1micB-4pmwA:
undetectable		 1micA-4pmwA:
2.64
1micB-4pmwA:
2.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 12 LEU A 717
LEU A 713
PHE A 697
ALA A 590
ALA A 587
 None
 0.90A 1n5xA-4pmwA:
undetectable		 1n5xA-4pmwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 12 LEU A 717
LEU A 713
PHE A 697
ALA A 590
ALA A 587
 None
 0.90A 1n5xB-4pmwA:
undetectable		 1n5xB-4pmwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 LYS A 281
TYR A 263
PRO A 279
 None
 1.10A 2j9cC-4pmwA:
undetectable		 2j9cC-4pmwA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		4 / 6 ILE A 483
ARG A 369
PRO A 354
SER A 356
 None
 1.48A 2qd3B-4pmwA:
undetectable		 2qd3B-4pmwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 LEU A 442
PRO A 443
LEU A 446
 None
 0.42A 2qd5B-4pmwA:
undetectable		 2qd5B-4pmwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 12 PHE A 462
VAL A 591
SER A 720
ALA A 716
ARG A 481
 None
 1.49A 2qm9A-4pmwA:
undetectable		 2qm9A-4pmwA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		4 / 6 GLN A 722
ALA A 714
ALA A 716
THR A 598
 None
 1.09A 2xfhA-4pmwA:
undetectable		 2xfhA-4pmwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		4 / 8 LEU A 713
PHE A 697
ALA A 590
ALA A 587
 None
 0.95A 3ax9B-4pmwA:
2.8		 3ax9B-4pmwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 LEU A 849
GLU A 326
ILE A 327
 None
 0.60A 3czhA-4pmwA:
undetectable		 3czhA-4pmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 LYS A 437
ILE A 300
PHE A 299
 None
 0.64A 3j7zS-4pmwA:
undetectable
3j7za-4pmwA:
undetectable		 3j7zS-4pmwA:
9.57
3j7za-4pmwA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 9 PHE A 479
ARG A 481
ALA A 714
LEU A 717
GLY A 480
 None
 1.19A 3pcqA-4pmwA:
undetectable		 3pcqA-4pmwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		4 / 5 GLU A 762
LEU A 759
GLN A 566
GLY A 567
 None
 1.28A 3pp1A-4pmwA:
undetectable		 3pp1A-4pmwA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 11 ALA A 848
LEU A 298
ILE A 334
LEU A 750
THR A 847
 None
 1.10A 3tqbA-4pmwA:
undetectable		 3tqbA-4pmwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 LEU A 442
PRO A 443
LEU A 446
 None
 0.44A 3w1wB-4pmwA:
undetectable		 3w1wB-4pmwA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		4 / 8 LEU A 450
CYH A 451
PHE A 414
PRO A 443
 None
 1.19A 4j7uD-4pmwA:
undetectable		 4j7uD-4pmwA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 12 SER A 486
THR A 488
ALA A 393
ALA A 391
ASP A 381
 None
None
None
None
MG  A 901 (-2.5A)
 1.40A 5d0xH-4pmwA:
undetectable
5d0xI-4pmwA:
undetectable		 5d0xH-4pmwA:
15.85
5d0xI-4pmwA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 ASP A 739
ARG A 272
ARG A  74
 None
None
U  C   7 ( 3.4A)
 0.83A 5eajB-4pmwA:
undetectable		 5eajB-4pmwA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		4 / 5 SER A 641
TYR A 687
SER A 617
ASP A 631
 None
 1.49A 5fhrA-4pmwA:
undetectable		 5fhrA-4pmwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 ILE A  85
PRO A  86
ILE A  94
 None
 0.37A 5hw8F-4pmwA:
undetectable		 5hw8F-4pmwA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		3 / 3 VAL A 233
VAL A 113
GLN A  70
 None
 0.56A 5qgnA-4pmwA:
undetectable		 5qgnA-4pmwA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4pmw DIS3-LIKE
EXONUCLEASE 2
(Mus
musculus) 		5 / 12 LEU A 265
ASP A 282
ILE A 303
PRO A 268
SER A 267
 None
None
None
None
U  C   1 ( 3.7A)
 0.84A 5t2zA-4pmwA:
undetectable		 5t2zA-4pmwA:
7.32