SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A 228
GLU A 255
ARG A 256
LYS A 243
 None
 1.49A 1yc2A-4pn0A:
undetectable
1yc2B-4pn0A:
undetectable
1yc2E-4pn0A:
undetectable		 1yc2A-4pn0A:
21.07
1yc2B-4pn0A:
21.07
1yc2E-4pn0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		4 / 8 THR A  58
ARG A 296
LEU A  65
ASP A 268
 None
 1.05A 2zw9A-4pn0A:
undetectable		 2zw9A-4pn0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 185
ILE A 202
PHE A 200
 None
 1.01A 3j7zS-4pn0A:
undetectable
3j7za-4pn0A:
undetectable		 3j7zS-4pn0A:
16.91
3j7za-4pn0A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A  65
SER A  62
PHE A  64
ILE A 204
 None
 0.97A 3ko0B-4pn0A:
undetectable		 3ko0B-4pn0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A  57
LEU A  65
PHE A 263
VAL A 288
ALA A  81
 None
 1.40A 3u9fD-4pn0A:
undetectable
3u9fE-4pn0A:
undetectable		 3u9fD-4pn0A:
21.17
3u9fE-4pn0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 268
ARG A 286
PRO A 283
 None
 0.60A 4wanC-4pn0A:
undetectable		 4wanC-4pn0A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 230
PHE A 135
ARG A 136
 None
 0.88A 4xr4B-4pn0A:
undetectable		 4xr4B-4pn0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG A 203
SER A 205
GLU A 260
GLU A  80
 None
 1.32A 4xzkA-4pn0A:
undetectable		 4xzkA-4pn0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 147
SER A 138
PHE A 135
ILE A 239
LEU A 290
 None
 1.34A 5ljbA-4pn0A:
undetectable		 5ljbA-4pn0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 284
VAL A 288
SER A 205
LEU A 191
ILE A  61
 None
 1.30A 6fdyU-4pn0A:
undetectable		 6fdyU-4pn0A:
23.58