SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.01A 1eqhA-4pn3A:
undetectable		 1eqhA-4pn3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.00A 1eqhB-4pn3A:
undetectable		 1eqhB-4pn3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 11 SER A 213
VAL A 214
GLY A 211
LEU A 220
GLU A 225
 None
 1.34A 1iolA-4pn3A:
25.5		 1iolA-4pn3A:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		7 / 11 GLY A  12
SER A  15
ASP A  36
ASP A  59
VAL A  60
ALA A  87
VAL A  89
 None
 0.56A 1uayA-4pn3A:
35.9		 1uayA-4pn3A:
54.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		7 / 10 GLY A  12
SER A  15
ASP A  36
ASP A  59
VAL A  60
ALA A  87
VAL A  89
 None
 0.53A 1uayB-4pn3A:
36.4		 1uayB-4pn3A:
54.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 GLY A  12
GLY A  14
ASP A  59
VAL A  60
ILE A 113
 None
 0.67A 1zq9B-4pn3A:
6.0		 1zq9B-4pn3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 ILE A  80
ALA A  73
GLN A  56
ALA A  72
ILE A 143
 None
 1.11A 2aclC-4pn3A:
undetectable		 2aclC-4pn3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 GLY A  14
ASP A  36
ASN A  38
ASP A  59
VAL A  60
 None
 0.69A 3ay0B-4pn3A:
7.0		 3ay0B-4pn3A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ASN A 145
THR A 172
VAL A 175
VAL A 230
ILE A 233
 None
 1.41A 3em0A-4pn3A:
undetectable		 3em0A-4pn3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.01A 3n8zA-4pn3A:
undetectable		 3n8zA-4pn3A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.03A 4ph9A-4pn3A:
undetectable		 4ph9A-4pn3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 10 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.03A 4ph9B-4pn3A:
undetectable		 4ph9B-4pn3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 CYH A  86
GLY A  16
GLY A  18
ALA A 227
VAL A  21
 None
 1.44A 5v3cA-4pn3A:
2.3		 5v3cA-4pn3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 TYR A 226
CYH A  86
GLY A  16
GLY A  18
VAL A  21
 None
 1.33A 5v3cA-4pn3A:
2.3		 5v3cA-4pn3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 GLY A  12
GLY A  14
ASP A  36
ASN A  38
VAL A  60
 None
 0.62A 5wy0A-4pn3A:
5.8		 5wy0A-4pn3A:
18.98