SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4png'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4png LD04004P
(Drosophila
melanogaster) 		4 / 7 VAL A 152
LEU A 142
LEU A 171
ALA A 111
 None
 0.81A 1j8uA-4pngA:
undetectable		 1j8uA-4pngA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4png LD04004P
(Drosophila
melanogaster) 		4 / 7 PHE A 174
SER A 166
PHE A 209
PHE A 108
 None
None
None
GSF  A2001 (-3.8A)
 1.01A 1qcaA-4pngA:
undetectable		 1qcaA-4pngA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4png LD04004P
(Drosophila
melanogaster) 		4 / 5 ILE A 165
SER A 166
PHE A 108
PRO A  14
 None
None
GSF  A2001 (-3.8A)
GSF  A2001 (-4.6A)
 1.35A 3bjwC-4pngA:
undetectable		 3bjwC-4pngA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4png LD04004P
(Drosophila
melanogaster) 		3 / 3 ASN A 110
ALA A 134
ARG A 131
 None
 0.77A 3tj7C-4pngA:
undetectable
3tj7D-4pngA:
undetectable		 3tj7C-4pngA:
23.08
3tj7D-4pngA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4png LD04004P
(Drosophila
melanogaster) 		4 / 7 PHE A 108
HIS A  69
ILE A  72
PRO A  14
 GSF  A2001 (-3.8A)
GSF  A2001 (-3.9A)
None
GSF  A2001 (-4.6A)
 1.18A 4g5jA-4pngA:
undetectable		 4g5jA-4pngA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4png LD04004P
(Drosophila
melanogaster) 		4 / 6 ASP A 133
GLU A 137
ASN A 110
ARG A 131
 None
 1.26A 4ntxA-4pngA:
3.0
4ntxC-4pngA:
undetectable		 4ntxA-4pngA:
18.71
4ntxC-4pngA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4png LD04004P
(Drosophila
melanogaster) 		4 / 6 ARG A  99
LEU A 100
ALA A  73
GLN A  98
 None
 0.91A 6b89B-4pngA:
undetectable		 6b89B-4pngA:
21.43