SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4po2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		3 / 3 GLU A 543
ALA A 541
SER A 537
 None
None
PO4  A 702 (-2.7A)
 0.58A 1errB-4po2A:
undetectable		 1errB-4po2A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		4 / 6 ALA A 565
LYS A 568
LYS A 569
ASP A 572
 None
 0.32A 1iwhA-4po2A:
undetectable		 1iwhA-4po2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		4 / 7 LEU A 456
LEU A 510
GLU A 514
MET A 518
 None
 1.02A 1linA-4po2A:
undetectable		 1linA-4po2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		5 / 12 PRO A 421
ILE A 503
GLY A 484
THR A 504
ALA A 397
 None
 1.10A 1nv8A-4po2A:
2.9		 1nv8A-4po2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		4 / 6 GLU A 543
TYR A 431
LYS A 550
PHE A 547
 None
 1.28A 2vmyA-4po2A:
undetectable		 2vmyA-4po2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		5 / 11 VAL A 442
PHE A 428
GLY A 408
GLY A 407
ASN A 540
 None
 1.24A 3owxA-4po2A:
undetectable
3owxB-4po2A:
undetectable		 3owxA-4po2A:
20.61
3owxB-4po2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B
(Homo
sapiens) 		5 / 11 VAL A 442
PHE A 428
GLY A 408
GLY A 407
ASN A 540
 None
 1.22A 4zvmA-4po2A:
undetectable
4zvmB-4po2A:
undetectable		 4zvmA-4po2A:
20.31
4zvmB-4po2A:
20.31