SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4po6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 10 LEU A 426
ASP A 382
VAL A 420
ILE A 324
GLY A 322
 None
 1.20A 1d4sA-4po6A:
undetectable		 1d4sA-4po6A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 GLY A 140
ARG A 124
LEU B 492
PHE A 459
 None
 0.91A 1gsfC-4po6A:
2.2		 1gsfC-4po6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 7 GLU A 159
LEU A 263
THR A 272
TYR A 108
 None
None
GOL  A 603 (-4.2A)
None
 1.26A 1rmtB-4po6A:
undetectable		 1rmtB-4po6A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 419
ILE A 395
PHE A 377
GLY A 323
TYR A 423
 None
 1.39A 1td7A-4po6A:
undetectable		 1td7A-4po6A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 10 LEU A 529
GLY A 530
PHE A 514
LEU A 483
ILE A 507
 None
 0.90A 2f8dA-4po6A:
undetectable		 2f8dA-4po6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 10 LEU A 529
GLY A 530
PHE A 514
LEU A 483
ILE A 507
 None
 0.91A 2f8dB-4po6A:
undetectable		 2f8dB-4po6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 170
ALA A 165
LEU A 167
SER A 218
 None
 1.01A 3cfqA-4po6A:
undetectable		 3cfqA-4po6A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		3 / 3 GLU B 497
HIS A 474
THR A 477
 None
 0.63A 3hkuA-4po6B:
undetectable		 3hkuA-4po6B:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 LEU A 263
THR A 262
ALA A 261
LEU A 152
LEU A 189
 None
 1.04A 3hm1A-4po6A:
undetectable		 3hm1A-4po6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 PHE A 160
THR A 262
ALA A 165
ALA A 267
 None
 1.23A 3ns1C-4po6A:
undetectable		 3ns1C-4po6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 LEU A 144
TYR A 423
ARG A 124
GLY A 320
THR A 319
 None
 1.27A 3okxA-4po6A:
undetectable		 3okxA-4po6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 5 HIS A 385
SER A 394
ASP A 399
THR A 384
 None
 1.26A 3okxB-4po6A:
undetectable		 3okxB-4po6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 GLU B 500
PRO A 506
LYS B 501
GLU A 517
 None
 1.33A 4a7tA-4po6B:
undetectable		 4a7tA-4po6B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 GLU B 500
PRO A 506
LYS B 501
GLU A 517
 None
 1.34A 4a7tF-4po6B:
undetectable		 4a7tF-4po6B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 GLU B 500
PRO A 506
LYS B 501
GLU A 517
 None
 1.32A 4a7uA-4po6B:
undetectable		 4a7uA-4po6B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 170
ALA A 165
LEU A 167
SER A 218
 None
 0.94A 4ikiB-4po6A:
undetectable		 4ikiB-4po6A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 7 LEU A 170
ALA A 165
LEU A 167
SER A 218
 None
 0.92A 4iklA-4po6A:
undetectable
4iklB-4po6A:
undetectable		 4iklA-4po6A:
12.85
4iklB-4po6A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 LEU A 170
ALA A 165
LEU A 167
SER A 218
 None
 0.94A 4iklA-4po6A:
undetectable
4iklB-4po6A:
undetectable		 4iklA-4po6A:
12.85
4iklB-4po6A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 11 LEU A  73
SER A 148
LEU B 492
LEU A 426
LEU A 144
 None
 1.16A 4or0A-4po6A:
undetectable		 4or0A-4po6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 LEU A 419
GLU A 315
VAL A 275
THR A 272
ARG A 274
 None
None
None
GOL  A 603 (-4.2A)
GOL  A 603 (-4.2A)
 1.23A 4q15B-4po6A:
undetectable		 4q15B-4po6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 ILE A 105
GLU A 264
GLY A 271
THR A 319
 None
 0.72A 4r20A-4po6A:
undetectable		 4r20A-4po6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A  32
ILE A  60
ALA A  61
ALA A 147
 None
 0.76A 4zf8A-4po6A:
undetectable		 4zf8A-4po6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 ILE A 395
VAL A 316
LEU A 407
SER A 418
VAL A 417
 None
 1.25A 5km9B-4po6A:
undetectable		 5km9B-4po6A:
13.48