SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4poo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
4 / 7 SER A  86
PHE A  51
ALA A  84
ILE A 129
None
1.07A 1fxhA-4pooA:
undetectable
1fxhB-4pooA:
undetectable
1fxhA-4pooA:
22.92
1fxhB-4pooA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 11 PHE A 100
LEU A 138
ALA A 166
VAL A 140
LEU A 155
None
0.98A 1rlbF-4pooA:
undetectable
1rlbF-4pooA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 LEU A  13
LEU A 135
ALA A  98
LEU A 126
ILE A 183
None
1.01A 1s9pA-4pooA:
undetectable
1s9pA-4pooA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 LEU A  13
LEU A 135
ALA A  98
LEU A 126
ILE A 183
None
1.05A 1s9pC-4pooA:
undetectable
1s9pC-4pooA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 LEU A  13
LEU A 135
ALA A  98
LEU A 126
ILE A 183
None
1.09A 1s9pD-4pooA:
undetectable
1s9pD-4pooA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
9 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.34A 3eeyA-4pooA:
29.6
3eeyA-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 ASN A  31
ILE A  53
GLN A  54
LEU A 105
THR A 113
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
None
1.10A 3eeyB-4pooA:
29.9
3eeyB-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
10 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
GLN A  54
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.42A 3eeyB-4pooA:
29.9
3eeyB-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
9 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.35A 3eeyC-4pooA:
30.1
3eeyC-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
10 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
PRO A 106
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-4.1A)
0.43A 3eeyD-4pooA:
30.0
3eeyD-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
9 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.40A 3eeyE-4pooA:
29.7
3eeyE-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
8 / 12 THR A  28
GLY A  30
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.51A 3eeyF-4pooA:
29.6
3eeyF-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
9 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.54A 3eeyH-4pooA:
30.0
3eeyH-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
9 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.49A 3eeyI-4pooA:
29.9
3eeyI-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 ASN A  31
ASP A  52
ILE A  53
LEU A 105
THR A 113
SAM  A 301 (-4.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
None
1.15A 3eeyJ-4pooA:
29.6
3eeyJ-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
10 / 12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ASP A  52
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
0.46A 3eeyJ-4pooA:
29.6
3eeyJ-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
4 / 5 ALA A 185
GLU A 187
ALA A  17
MET A 130
None
1.28A 3r9tC-4pooA:
undetectable
3r9tC-4pooA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
4 / 4 ALA A  50
VAL A  48
ASP A  26
LEU A  65
None
None
SAM  A 301 ( 4.6A)
None
1.40A 4e7gA-4pooA:
4.2
4e7gA-4pooA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 THR A  28
ASN A  31
ASP A  26
LEU A 105
THR A 114
SAM  A 301 (-4.1A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
1.34A 4pooA-4pooA:
38.7
4pooA-4pooA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
12 / 12 THR A  28
GLY A  30
ASN A  31
HIS A  33
ASP A  34
ILE A  53
SER A  79
HIS A  80
ASN A 101
LEU A 105
THR A 114
SER A 118
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
SAM  A 301 ( 3.8A)
0.00A 4pooA-4pooA:
38.7
4pooA-4pooA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
6 / 12 ASN A  60
ASP A  52
ILE A  53
GLN A  54
SER A  79
HIS A  80
None
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.1A)
1.42A 4pooB-4pooA:
30.9
4pooB-4pooA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 GLY A  30
ASN A  31
HIS A  33
ILE A 112
ASN A 101
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-4.1A)
1.37A 4pooB-4pooA:
30.9
4pooB-4pooA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
11 / 12 THR A  28
GLY A  30
ASN A  31
HIS A  33
ASP A  34
ASP A  52
ILE A  53
SER A  79
HIS A  80
ASN A 101
SER A 118
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 ( 3.8A)
0.43A 4pooB-4pooA:
30.9
4pooB-4pooA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
9 / 12 THR A  28
GLY A  30
HIS A  33
ASP A  52
ILE A  53
GLN A  54
SER A  79
HIS A  80
SER A 118
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.8A)
0.68A 4pooB-4pooA:
30.9
4pooB-4pooA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis)
5 / 12 GLY A  30
ASP A  52
ILE A  53
SER A  79
TYR A 141
SAM  A 301 (-3.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
None
0.60A 4rtsA-4pooA:
10.0
4rtsA-4pooA:
21.64