SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4pot VP1
(Human
polyomavirus
9) 		3 / 3 GLN A 133
HIS A 274
PRO A 147
 NGC  A 407 (-4.3A)
NGC  A 407 (-3.7A)
None
 0.87A 1d8cA-4potA:
undetectable		 1d8cA-4potA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4pot VP1
(Human
polyomavirus
9) 		4 / 8 GLY A 255
GLU A 114
ALA A 115
ASN A 221
 None
 0.77A 2dtjA-4potA:
undetectable
2dtjB-4potA:
undetectable		 2dtjA-4potA:
21.58
2dtjB-4potA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4pot VP1
(Human
polyomavirus
9) 		4 / 6 MET A 123
LEU A 286
MET A  56
TYR A  51
 None
 1.08A 3mnpA-4potA:
undetectable		 3mnpA-4potA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4pot VP1
(Human
polyomavirus
9) 		5 / 9 ALA A 170
GLY A 167
ILE A 183
PRO A 208
LEU A  88
 None
 1.27A 3u7sB-4potA:
undetectable		 3u7sB-4potA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4pot VP1
(Human
polyomavirus
9) 		5 / 12 TYR A 225
GLY A 159
ASN A 219
PHE A 156
LEU A 265
 None
None
None
IPA  A 404 (-4.6A)
None
 1.20A 3vywB-4potA:
undetectable		 3vywB-4potA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4pot VP1
(Human
polyomavirus
9) 		3 / 3 MET A 123
MET A  56
TYR A  51
 None
 0.99A 4p6xI-4potA:
undetectable		 4p6xI-4potA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pot VP1
(Human
polyomavirus
9) 		5 / 12 ALA A 267
VAL A 122
GLY A 124
SER A 127
LEU A 128
 None
EDO  A 403 (-4.4A)
None
None
None
 1.06A 5kirA-4potA:
undetectable		 5kirA-4potA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pot VP1
(Human
polyomavirus
9) 		5 / 12 ALA A 267
VAL A 122
GLY A 124
SER A 127
LEU A 128
 None
EDO  A 403 (-4.4A)
None
None
None
 1.12A 5kirB-4potA:
undetectable		 5kirB-4potA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4pot VP1
(Human
polyomavirus
9) 		5 / 12 ASN A 276
SER A 143
GLY A 144
THR A 145
GLN A 133
 NGC  A 407 (-3.5A)
None
None
None
NGC  A 407 (-4.3A)
 1.42A 5oj0A-4potA:
undetectable		 5oj0A-4potA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4pot VP1
(Human
polyomavirus
9) 		4 / 6 PRO A 256
LEU A 265
PHE A 156
LEU A 163
 None
None
IPA  A 404 (-4.6A)
None
 1.03A 5tl8A-4potA:
undetectable		 5tl8A-4potA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4pot VP1
(Human
polyomavirus
9) 		4 / 6 THR A 145
LEU A 131
THR A 275
LEU A 128
 None
 1.15A 6mvxA-4potA:
undetectable
6mvxB-4potA:
undetectable
6mvxC-4potA:
undetectable		 6mvxA-4potA:
21.41
6mvxB-4potA:
21.41
6mvxC-4potA:
21.41