SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY C  91
TYR D 104
ASN C  31
TYR C  50
GLN C  27
 None
 1.14A 1h1dA-4pp1C:
undetectable		 1h1dA-4pp1C:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus) 		7 / 12 TYR C  36
GLN C  89
PHE C  97
ASN D  35
VAL D  37
ALA D  96
TRP D 110
 None
 0.78A 1h8sA-4pp1C:
21.4		 1h8sA-4pp1C:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus) 		4 / 7 TYR D 105
GLY D  33
TYR D 102
ASP D  72
 None
 1.05A 2g72B-4pp1D:
undetectable		 2g72B-4pp1D:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus;
Mus
musculus) 		4 / 8 MET C 174
LEU C 135
SER D 185
VAL C 158
 None
 0.87A 2qd2A-4pp1C:
undetectable		 2qd2A-4pp1C:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY C  91
TYR D 104
ASN C  31
TYR C  50
GLN C  27
 None
 1.15A 2zthA-4pp1C:
undetectable		 2zthA-4pp1C:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus) 		3 / 3 ASN D  60
ASP D  89
GLN D  86
 None
 0.72A 3eeyC-4pp1D:
undetectable		 3eeyC-4pp1D:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus) 		3 / 3 ASN D  60
ASP D  89
GLN D  86
 None
 0.74A 3eeyD-4pp1D:
undetectable		 3eeyD-4pp1D:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus) 		3 / 3 ASN D  60
ASP D  89
GLN D  86
 None
 0.73A 3eeyE-4pp1D:
undetectable		 3eeyE-4pp1D:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus) 		4 / 4 LEU C  15
GLY C  16
LEU C  78
GLU C  79
 None
 1.03A 3tgvB-4pp1C:
undetectable		 3tgvB-4pp1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
(Mus
musculus;
Mus
musculus) 		4 / 5 LYS D  71
ALA D  98
ASP D 108
ASN C  34
 None
 1.40A 4obwC-4pp1D:
0.0		 4obwC-4pp1D:
17.67