SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		3 / 3 LEU A  27
SER A  24
ASN A 158
 None
 0.76A 1bx4A-4pphA:
undetectable		 1bx4A-4pphA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		5 / 12 LEU A 317
LEU A 287
LEU A 333
VAL A 242
VAL A 247
 None
 1.01A 2pnjA-4pphA:
undetectable		 2pnjA-4pphA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		4 / 7 ARG A 193
ILE A 344
GLY A 361
TYR A 319
 None
 0.87A 2tsrA-4pphA:
undetectable		 2tsrA-4pphA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		4 / 6 HIS A  51
PHE A 144
LEU A 103
LEU A 118
 EDO  A 509 ( 4.1A)
None
None
None
 0.95A 3bgdA-4pphA:
undetectable		 3bgdA-4pphA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		5 / 9 LEU A 333
VAL A 242
LEU A 287
ILE A 373
PHE A 295
 None
 1.13A 3tbgD-4pphA:
undetectable		 3tbgD-4pphA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		4 / 6 PRO A 108
SER A  24
VAL A 160
THR A 281
 None
 1.08A 3tneA-4pphA:
25.4		 3tneA-4pphA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		4 / 7 VAL A 351
VAL A 363
PHE A 362
ILE A 344
 None
 0.99A 3zjqB-4pphA:
undetectable		 3zjqB-4pphA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		4 / 5 LEU A 177
ILE A 201
LEU A 164
LEU A  38
 None
 0.86A 4o8fA-4pphA:
undetectable		 4o8fA-4pphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		5 / 12 VAL A 189
LEU A 191
ILE A 201
LEU A 164
HIS A  28
 None
 1.00A 4p65B-4pphA:
undetectable
4p65D-4pphA:
undetectable
4p65I-4pphA:
undetectable
4p65J-4pphA:
undetectable		 4p65B-4pphA:
9.96
4p65D-4pphA:
9.96
4p65I-4pphA:
4.42
4p65J-4pphA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4pph CONGLUTIN GAMMA
(Lupinus
angustifolius) 		4 / 8 SER A 105
ALA A 119
LEU A 118
GLY A 102
 EDO  A 509 ( 4.9A)
None
None
None
 1.01A 4xk8a-4pphA:
undetectable		 4xk8a-4pphA:
19.65