SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ppm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 GLY A 650
GLY A 448
LEU A 427
ASP A 437
 None
 0.81A 1aegA-4ppmA:
undetectable		 1aegA-4ppmA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 10 THR A 620
ALA A 630
LEU A 599
VAL A 602
ILE A 636
 None
 0.99A 1claA-4ppmA:
undetectable		 1claA-4ppmA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 LEU A 613
LEU A 663
LEU A 568
LEU A 565
 None
 0.83A 1errA-4ppmA:
undetectable		 1errA-4ppmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 PHE A 837
ILE A 823
LEU A 718
LEU A 736
 None
 0.74A 1eupA-4ppmA:
0.0		 1eupA-4ppmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 PHE A 629
GLY A 623
ARG A 624
LEU A 827
 None
 0.83A 1gsfA-4ppmA:
undetectable		 1gsfA-4ppmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 PHE A 629
GLY A 623
ARG A 624
LEU A 827
 None
 0.84A 1gsfB-4ppmA:
undetectable		 1gsfB-4ppmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 PHE A 629
GLY A 623
ARG A 624
LEU A 827
 None
 0.84A 1gsfC-4ppmA:
undetectable		 1gsfC-4ppmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 PHE A 629
GLY A 623
ARG A 624
LEU A 827
 None
 0.84A 1gsfD-4ppmA:
undetectable		 1gsfD-4ppmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 5 LEU A 458
ALA A 687
LEU A 651
SER A 648
 None
 1.13A 1tt6B-4ppmA:
undetectable		 1tt6B-4ppmA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 5 LEU A 565
LEU A 599
CYH A 606
THR A 609
 None
 1.08A 2oaxD-4ppmA:
undetectable		 2oaxD-4ppmA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 10 VAL A 591
ILE A 585
LEU A 827
GLY A 626
ALA A 707
 None
 1.18A 2xf3A-4ppmA:
undetectable		 2xf3A-4ppmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 9 VAL A 591
ILE A 585
LEU A 827
GLY A 626
ALA A 707
 None
 1.18A 2xf3B-4ppmA:
undetectable		 2xf3B-4ppmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 9 VAL A 591
ILE A 585
LEU A 827
GLY A 626
ALA A 707
 None
 1.19A 2xfsB-4ppmA:
undetectable		 2xfsB-4ppmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 9 VAL A 591
ILE A 585
LEU A 827
GLY A 626
ALA A 707
 None
 1.22A 2xh9B-4ppmA:
undetectable		 2xh9B-4ppmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 5 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.43A 3ablC-4ppmA:
undetectable
3ablJ-4ppmA:
undetectable		 3ablC-4ppmA:
14.00
3ablJ-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		3 / 3 GLY A 626
GLY A 711
GLY A 735
 None
 0.43A 3bogD-4ppmA:
undetectable		 3bogD-4ppmA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLY A 589
TYR A 530
GLU A 583
ASN A 816
 None
PLP  A 902 (-4.8A)
PLP  A 902 (-4.1A)
None
 1.12A 3e9rC-4ppmA:
undetectable		 3e9rC-4ppmA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 7 GLY A 739
GLN A 741
VAL A 820
ILE A 585
 None
 0.88A 3fi0P-4ppmA:
undetectable		 3fi0P-4ppmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 12 GLY A 441
ARG A 822
ASN A 450
GLY A 649
SER A 646
 None
 1.28A 3k13B-4ppmA:
undetectable		 3k13B-4ppmA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 ASP A 416
LEU A 395
ASP A 430
ASP A 429
 None
 1.22A 3n2oC-4ppmA:
undetectable
3n2oD-4ppmA:
undetectable		 3n2oC-4ppmA:
23.39
3n2oD-4ppmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 5 ALA A 510
GLU A 508
ALA A 537
MET A 557
 None
 1.14A 3r9tC-4ppmA:
undetectable		 3r9tC-4ppmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 PHE A 714
PHE A 841
ALA A 840
THR A 843
 None
 1.07A 3t3sB-4ppmA:
undetectable		 3t3sB-4ppmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 11 GLY A 503
VAL A 507
GLU A 508
SER A 502
VAL A 618
 PLP  A 902 (-3.3A)
None
None
PLP  A 902 ( 3.9A)
PLP  A 902 (-4.4A)
 1.28A 4danA-4ppmA:
undetectable		 4danA-4ppmA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLU A 833
ASP A 437
ASN A 446
ARG A 624
 None
 1.40A 4ntxA-4ppmA:
undetectable
4ntxC-4ppmA:
undetectable		 4ntxA-4ppmA:
19.41
4ntxC-4ppmA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		3 / 3 PHE A 562
THR A 625
LEU A 599
 None
 0.62A 4qztA-4ppmA:
undetectable		 4qztA-4ppmA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		5 / 12 GLY A 443
GLY A 441
SER A 646
LEU A 622
ALA A 694
 None
 1.03A 4uckB-4ppmA:
undetectable		 4uckB-4ppmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		3 / 3 CYH A 804
LYS A 802
HIS A 807
 None
 0.99A 5js5A-4ppmA:
undetectable		 5js5A-4ppmA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.10A 5z84P-4ppmA:
undetectable
5z84W-4ppmA:
undetectable		 5z84P-4ppmA:
14.00
5z84W-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.07A 5z85P-4ppmA:
undetectable
5z85W-4ppmA:
undetectable		 5z85P-4ppmA:
14.00
5z85W-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.10A 5z86P-4ppmA:
undetectable
5z86W-4ppmA:
undetectable		 5z86P-4ppmA:
14.00
5z86W-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.10A 5zcoP-4ppmA:
undetectable
5zcoW-4ppmA:
undetectable		 5zcoP-4ppmA:
14.00
5zcoW-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.12A 5zcpC-4ppmA:
undetectable
5zcpJ-4ppmA:
undetectable		 5zcpC-4ppmA:
14.00
5zcpJ-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.08A 5zcpP-4ppmA:
undetectable
5zcpW-4ppmA:
undetectable		 5zcpP-4ppmA:
14.00
5zcpW-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 4 GLY A 448
ARG A 624
ASN A 446
LEU A 445
 None
 1.36A 6b58A-4ppmA:
undetectable		 6b58A-4ppmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		3 / 3 GLU A 570
ASP A 564
PRO A 561
 None
 0.73A 6berA-4ppmA:
undetectable		 6berA-4ppmA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 8 ILE A 582
ALA A 524
VAL A 558
MET A 557
 None
 1.03A 6hu9a-4ppmA:
undetectable
6hu9e-4ppmA:
undetectable		 6hu9a-4ppmA:
21.49
6hu9e-4ppmA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ppm AMINOTRANSFERASE
(Serratia
sp.
FS14) 		4 / 6 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.21A 6nmpC-4ppmA:
undetectable
6nmpJ-4ppmA:
undetectable		 6nmpC-4ppmA:
14.00
6nmpJ-4ppmA:
5.99