SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ppr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.38A 1ghmA-4pprA:
19.6		 1ghmA-4pprA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.40A 1i2wA-4pprA:
20.3		 1i2wA-4pprA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 120
SER A 121
LYS A 124
SER A 176
ASN A 178
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.32A 1i2wB-4pprA:
20.4		 1i2wB-4pprA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 8 THR A 225
LEU A 309
VAL A 307
VAL A 125
 None
 1.15A 1uyuA-4pprA:
undetectable		 1uyuA-4pprA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 SER A 121
LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.28A 1ymxA-4pprA:
20.1		 1ymxA-4pprA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 SER A 121
LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.27A 1ymxB-4pprA:
20.0		 1ymxB-4pprA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 294
LEU A  98
PHE A 233
THR A 225
 None
 0.91A 2f78A-4pprA:
undetectable		 2f78A-4pprA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 294
LEU A  98
PHE A 233
THR A 225
 None
 0.91A 2f78B-4pprA:
undetectable		 2f78B-4pprA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 229
PHE A 233
SER A 224
ARG A 116
 None
 1.50A 2v7uB-4pprA:
undetectable		 2v7uB-4pprA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.42A 3hlwA-4pprA:
20.2		 3hlwA-4pprA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.31A 3hlwB-4pprA:
20.1		 3hlwB-4pprA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 LYS A 124
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 ( 4.1A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.38A 3huoA-4pprA:
20.0		 3huoA-4pprA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
LYS A 124
ASN A 178
LEU A 218
THR A 283
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-3.0A)
MER  A 400 (-4.2A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.45A 3mzeA-4pprA:
31.8		 3mzeA-4pprA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
LYS A 124
ASN A 178
THR A 283
GLY A 284
THR A 286
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
MER  A 400 ( 4.9A)
 0.59A 3mzeA-4pprA:
31.8		 3mzeA-4pprA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.43A 3q07A-4pprA:
20.0		 3q07A-4pprA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.41A 3q07B-4pprA:
19.8		 3q07B-4pprA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.31A 3sh8A-4pprA:
20.4		 3sh8A-4pprA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.44A 3sh8B-4pprA:
20.2		 3sh8B-4pprA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 172
GLY A 171
PHE A 243
ASN A 267
 None
 1.07A 3uq6B-4pprA:
undetectable		 3uq6B-4pprA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 229
GLY A 206
TYR A 228
 None
 0.75A 3w9tC-4pprA:
undetectable		 3w9tC-4pprA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 229
GLY A 206
TYR A 228
 None
 0.76A 3w9tG-4pprA:
undetectable		 3w9tG-4pprA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 LYS A 124
SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.47A 4euzA-4pprA:
19.7		 4euzA-4pprA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 SER A 176
ASN A 178
LEU A 218
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-4.2A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.79A 4euzA-4pprA:
19.7		 4euzA-4pprA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 330
ALA A 323
LEU A 326
GLY A 329
MET A 129
 None
 1.47A 4fe1A-4pprA:
undetectable
4fe1J-4pprA:
undetectable		 4fe1A-4pprA:
19.76
4fe1J-4pprA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 8 THR A 210
VAL A 125
VAL A 307
VAL A 294
 None
 0.99A 4l4bA-4pprA:
undetectable		 4l4bA-4pprA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.28A 4n9kA-4pprA:
20.5		 4n9kA-4pprA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.34A 4n9kB-4pprA:
20.6		 4n9kB-4pprA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  74
ALA A 100
LEU A 341
ILE A 108
 None
 0.85A 4ubsA-4pprA:
undetectable		 4ubsA-4pprA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 330
ALA A 323
LEU A 326
GLY A 329
 None
 0.98A 4xk8a-4pprA:
undetectable		 4xk8a-4pprA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.30A 5ghyA-4pprA:
20.2		 5ghyA-4pprA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.29A 5ghyB-4pprA:
20.3		 5ghyB-4pprA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 11 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.31A 5ghzA-4pprA:
20.3		 5ghzA-4pprA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		7 / 10 ALA A 120
SER A 121
SER A 176
ASN A 178
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.31A 5ghzB-4pprA:
20.3		 5ghzB-4pprA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 263
HIS A 175
MET A 174
 None
 0.75A 6af6A-4pprA:
undetectable		 6af6A-4pprA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 206
ILE A 342
ASP A 209
PRO A 113
 None
 1.01A 6ag0C-4pprA:
undetectable		 6ag0C-4pprA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 121
SER A 176
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.48A 6b5yD-4pprA:
20.0		 6b5yD-4pprA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 121
SER A 176
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.27A 6b68B-4pprA:
20.1		 6b68B-4pprA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 121
SER A 176
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.26A 6b69A-4pprA:
20.1
6b69B-4pprA:
20.0		 6b69A-4pprA:
13.46
6b69B-4pprA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 121
SER A 176
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.27A 6b6aD-4pprA:
19.8		 6b6aD-4pprA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 121
SER A 176
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.37A 6b6cA-4pprA:
20.1		 6b6cA-4pprA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 121
SER A 176
LYS A 282
THR A 283
GLY A 284
 MER  A 400 (-1.3A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.6A)
MER  A 400 (-3.1A)
 0.48A 6b6fA-4pprA:
20.0		 6b6fA-4pprA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 309
GLY A 115
LEU A  74
GLY A  70
 None
 0.71A 6eu9D-4pprA:
undetectable		 6eu9D-4pprA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 281
LEU A 173
ALA A 128
ALA A 237
PHE A 243
 None
 1.29A 6qgbA-4pprA:
0.5		 6qgbA-4pprA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4ppr PENICILLIN-BINDING
PROTEIN DACB1
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 281
LEU A 173
ALA A 128
ALA A 237
PHE A 243
 None
 1.25A 6qgbE-4pprA:
undetectable		 6qgbE-4pprA:
20.70