SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ppu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.31A 1nx9A-4ppuA:
undetectable		 1nx9A-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.30A 1nx9B-4ppuA:
undetectable		 1nx9B-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.30A 1nx9C-4ppuA:
undetectable		 1nx9C-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.30A 1nx9D-4ppuA:
undetectable		 1nx9D-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A 107
MET A 324
MET A 194
LEU A 226
 None
 1.26A 2oz7A-4ppuA:
undetectable		 2oz7A-4ppuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 PHE A 151
SER A 227
LEU A 223
 None
 0.83A 2w1bA-4ppuA:
3.5		 2w1bA-4ppuA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ALA A 272
ARG A 276
LYS A 280
 None
 0.73A 3kp3B-4ppuA:
undetectable		 3kp3B-4ppuA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ALA A 272
ARG A 276
LYS A 280
 None
 0.51A 3kp5B-4ppuA:
undetectable		 3kp5B-4ppuA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 THR A 283
GLY A 285
GLU A 287
LEU A 107
ILE A 103
 None
 1.39A 3nbqA-4ppuA:
undetectable		 3nbqA-4ppuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.78A 4q15A-4ppuA:
undetectable		 4q15A-4ppuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.76A 4q15B-4ppuA:
undetectable		 4q15B-4ppuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ASP A 155
ALA A 146
PHE A 151
SER A 153
GLY A 149
 None
None
None
TYR  A 401 ( 4.7A)
TYR  A 401 (-4.8A)
 1.21A 4xp1A-4ppuA:
undetectable		 4xp1A-4ppuA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.75A 4ydqB-4ppuA:
undetectable		 4ydqB-4ppuA:
17.13