SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ppy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		3 / 3 SER A  60
THR A 120
GLN A  90
 None
 0.86A 2fk8A-4ppyA:
2.8		 2fk8A-4ppyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		4 / 5 GLN A 227
PHE A  56
TRP A  65
GLY A  77
 None
 1.22A 2qmzA-4ppyA:
3.9
2qmzB-4ppyA:
3.9		 2qmzA-4ppyA:
21.40
2qmzB-4ppyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 10 GLY A  84
GLY A  85
GLU A  63
ASN A  67
VAL A  66
 None
 1.47A 4fgkA-4ppyA:
3.5
4fgkB-4ppyA:
3.9		 4fgkA-4ppyA:
21.40
4fgkB-4ppyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		4 / 5 GLY A  84
GLY A  85
ASN A 119
GLU A  63
 None
 1.14A 4fglC-4ppyA:
2.4		 4fglC-4ppyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		4 / 6 ASP A 220
TYR A 207
HIS A  69
THR A  68
 None
 1.33A 4paeA-4ppyA:
undetectable		 4paeA-4ppyA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.43A 4qvmV-4ppyA:
undetectable
4qvmb-4ppyA:
undetectable		 4qvmV-4ppyA:
21.05
4qvmb-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.43A 4qvmH-4ppyA:
undetectable
4qvmN-4ppyA:
undetectable		 4qvmH-4ppyA:
21.05
4qvmN-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.43A 4qvpV-4ppyA:
undetectable
4qvpb-4ppyA:
undetectable		 4qvpV-4ppyA:
21.05
4qvpb-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 4qvpH-4ppyA:
undetectable
4qvpN-4ppyA:
undetectable		 4qvpH-4ppyA:
21.05
4qvpN-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 4qvqV-4ppyA:
undetectable
4qvqb-4ppyA:
undetectable		 4qvqV-4ppyA:
21.05
4qvqb-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 4qvqH-4ppyA:
undetectable
4qvqN-4ppyA:
undetectable		 4qvqH-4ppyA:
21.05
4qvqN-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 4qw1V-4ppyA:
undetectable
4qw1b-4ppyA:
undetectable		 4qw1V-4ppyA:
21.05
4qw1b-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 4qw1H-4ppyA:
undetectable
4qw1N-4ppyA:
undetectable		 4qw1H-4ppyA:
21.05
4qw1N-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.41A 4qwuV-4ppyA:
undetectable
4qwub-4ppyA:
undetectable		 4qwuV-4ppyA:
21.05
4qwub-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.40A 4qwuH-4ppyA:
undetectable
4qwuN-4ppyA:
undetectable		 4qwuH-4ppyA:
21.05
4qwuN-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		4 / 4 ASN A  59
VAL A 212
THR A 151
ILE A 170
 None
 1.36A 4retA-4ppyA:
2.7		 4retA-4ppyA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		4 / 4 ASN A  59
VAL A 212
THR A 151
ILE A 170
 None
 1.36A 4retC-4ppyA:
2.5		 4retC-4ppyA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 12 ASN A 174
PHE A 157
LEU A  92
ASN A 110
MET A 135
 None
 1.43A 4zjlD-4ppyA:
1.1		 4zjlD-4ppyA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 SER A  88
THR A 128
ALA A 154
THR A 120
GLY A 121
 None
 1.28A 4zjoD-4ppyA:
undetectable		 4zjoD-4ppyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 9 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.45A 5cz7V-4ppyA:
undetectable
5cz7b-4ppyA:
0.3		 5cz7V-4ppyA:
21.05
5cz7b-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.45A 5cz7H-4ppyA:
undetectable
5cz7N-4ppyA:
undetectable		 5cz7H-4ppyA:
21.05
5cz7N-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 5l66V-4ppyA:
undetectable
5l66b-4ppyA:
undetectable		 5l66V-4ppyA:
21.05
5l66b-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 11 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.42A 5l66H-4ppyA:
undetectable
5l66N-4ppyA:
undetectable		 5l66H-4ppyA:
21.05
5l66N-4ppyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 12 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.40A 5lf3b-4ppyA:
undetectable		 5lf3b-4ppyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4ppy PUTATIVE
ACYLHYDROLASE
(Bacteroides
fragilis) 		5 / 12 THR A 151
THR A 150
THR A 149
ALA A 112
THR A 128
 None
 1.40A 5lf3N-4ppyA:
undetectable		 5lf3N-4ppyA:
20.96