SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ppz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 11 LEU A 252
LEU A 187
ALA A 275
VAL A 254
LEU A 213
None
1.13A 1kt7A-4ppzA:
undetectable
1kt7A-4ppzA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 ASP A  70
SER A 133
ILE A  52
GLU A 135
None
None
None
ZN  A 601 (-3.9A)
0.96A 1meiA-4ppzA:
undetectable
1meiA-4ppzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 6 TRP A 288
ASN A 186
LEU A 286
PHE A 256
None
1.40A 1rukH-4ppzA:
undetectable
1rukL-4ppzA:
undetectable
1rukH-4ppzA:
20.36
1rukL-4ppzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.90A 1v7zA-4ppzA:
4.8
1v7zA-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.91A 1v7zB-4ppzA:
4.8
1v7zB-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.92A 1v7zC-4ppzA:
4.8
1v7zC-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.91A 1v7zD-4ppzA:
4.8
1v7zD-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.90A 1v7zE-4ppzA:
4.8
1v7zE-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.91A 1v7zF-4ppzA:
4.8
1v7zF-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 LEU A 277
VAL A 282
GLY A 281
LEU A 216
ALA A 212
None
1.04A 2egvA-4ppzA:
undetectable
2egvA-4ppzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 LEU A 277
VAL A 282
GLY A 281
LEU A 216
ALA A 212
None
1.02A 2egvB-4ppzA:
undetectable
2egvB-4ppzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 THR A 326
THR A 166
VAL A 162
ALA A  66
VAL A 147
None
1.14A 2nniA-4ppzA:
undetectable
2nniA-4ppzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
6 / 12 ASN A  51
LEU A  13
ILE A 106
ALA A 107
THR A 111
LEU A  34
None
1.29A 3a50A-4ppzA:
undetectable
3a50A-4ppzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.94A 3a6jA-4ppzA:
4.8
3a6jA-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 7 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.93A 3a6jB-4ppzA:
4.7
3a6jB-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.94A 3a6jC-4ppzA:
4.6
3a6jC-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.94A 3a6jE-4ppzA:
4.6
3a6jE-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 GLU A 164
HIS A  68
ASP A 101
GLU A 136
ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
0.94A 3a6jF-4ppzA:
4.7
3a6jF-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 VAL A 356
ILE A 310
VAL A 367
GLY A 343
None
0.90A 3hjoB-4ppzA:
undetectable
3hjoB-4ppzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 6 LEU A  29
ILE A 106
ALA A 107
THR A 111
None
1.13A 3mdrA-4ppzA:
undetectable
3mdrA-4ppzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 6 LEU A  34
PHE A  39
ILE A 127
ALA A 128
None
0.75A 3mdrA-4ppzA:
undetectable
3mdrA-4ppzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 6 GLU A 164
ARG A 179
GLU A 135
GLU A 136
ZN  A 601 (-2.1A)
None
ZN  A 601 (-3.9A)
ZN  A 602 ( 1.9A)
1.23A 4kr3A-4ppzA:
undetectable
4kr3A-4ppzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 5 VAL A 282
LEU A 187
VAL A 254
PHE A 209
None
1.06A 4lb0B-4ppzA:
undetectable
4lb0B-4ppzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 10 LEU A 216
LEU A 213
ALA A 212
LEU A 252
LEU A 277
None
0.96A 4p65A-4ppzA:
undetectable
4p65B-4ppzA:
undetectable
4p65F-4ppzA:
undetectable
4p65H-4ppzA:
undetectable
4p65A-4ppzA:
4.92
4p65B-4ppzA:
7.89
4p65F-4ppzA:
7.89
4p65H-4ppzA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 11 LEU A 216
LEU A 213
ALA A 212
LEU A 277
LEU A 252
None
0.95A 4p65C-4ppzA:
undetectable
4p65D-4ppzA:
undetectable
4p65J-4ppzA:
undetectable
4p65L-4ppzA:
undetectable
4p65C-4ppzA:
4.92
4p65D-4ppzA:
7.89
4p65J-4ppzA:
7.89
4p65L-4ppzA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 11 LEU A 277
LEU A 252
LEU A 216
LEU A 213
ALA A 212
None
1.07A 4p65B-4ppzA:
undetectable
4p65D-4ppzA:
undetectable
4p65G-4ppzA:
undetectable
4p65H-4ppzA:
undetectable
4p65B-4ppzA:
7.89
4p65D-4ppzA:
7.89
4p65G-4ppzA:
4.92
4p65H-4ppzA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 LEU A 252
LEU A 277
LEU A 216
LEU A 213
ALA A 212
None
0.99A 4p65B-4ppzA:
undetectable
4p65D-4ppzA:
undetectable
4p65I-4ppzA:
undetectable
4p65J-4ppzA:
undetectable
4p65B-4ppzA:
7.89
4p65D-4ppzA:
7.89
4p65I-4ppzA:
4.92
4p65J-4ppzA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 LEU A 277
LEU A 252
LEU A 216
LEU A 213
ALA A 212
None
1.02A 4p65F-4ppzA:
undetectable
4p65H-4ppzA:
undetectable
4p65K-4ppzA:
undetectable
4p65L-4ppzA:
undetectable
4p65F-4ppzA:
7.89
4p65H-4ppzA:
7.89
4p65K-4ppzA:
4.92
4p65L-4ppzA:
7.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
11 / 11 HIS A  68
ASP A 101
GLU A 135
GLU A 136
GLU A 164
ARG A 179
GLY A 324
GLY A 325
ASN A 346
ILE A 349
HIS A 350
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 601 (-3.9A)
ZN  A 602 ( 1.9A)
ZN  A 601 (-2.1A)
None
None
PO4  A 603 ( 3.7A)
None
None
ZN  A 602 (-3.3A)
0.18A 4pqaA-4ppzA:
60.3
4pqaA-4ppzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
4 / 8 ILE A 276
PHE A 256
LEU A 216
LEU A 187
None
0.94A 4qopC-4ppzA:
undetectable
4qopC-4ppzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 TRP A  53
LEU A 130
CYH A  64
LEU A 156
ALA A 334
None
1.47A 5fctB-4ppzA:
undetectable
5fctB-4ppzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 GLU A 369
LEU A 342
ILE A 310
ALA A 309
GLU A 312
None
1.19A 5v0vA-4ppzA:
undetectable
5v0vA-4ppzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 GLY A  67
VAL A 162
THR A 326
GLY A 325
GLY A 324
None
None
None
PO4  A 603 ( 3.7A)
None
1.20A 6brdB-4ppzA:
2.7
6brdB-4ppzA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis)
5 / 12 GLY A 163
VAL A 162
THR A 326
GLY A 325
GLY A 324
None
None
None
PO4  A 603 ( 3.7A)
None
1.06A 6brdB-4ppzA:
2.7
6brdB-4ppzA:
13.65