SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 279
LEU A 357
LEU A 318
LEU A 306
 None
 1.22A 1a4lD-4pq0A:
undetectable		 1a4lD-4pq0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 4 THR A 353
LEU A 357
VAL A 360
LEU A 364
 None
 0.49A 1fbmD-4pq0A:
undetectable		 1fbmD-4pq0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 279
ASN A 264
LEU A 364
LEU A 345
LEU A 330
 None
 1.40A 1hwiA-4pq0A:
undetectable		 1hwiA-4pq0A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 4 THR A 353
LEU A 357
VAL A 360
LEU A 364
 None
 0.97A 1mz9D-4pq0A:
undetectable		 1mz9D-4pq0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 284
HIS A 296
SER A 287
VAL A 369
 None
 1.24A 1u1jA-4pq0A:
undetectable		 1u1jA-4pq0A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 266
ASP A 260
ILE A 261
PHE A 245
 None
 0.72A 4acaC-4pq0A:
undetectable		 4acaC-4pq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 266
ASP A 260
ILE A 261
PHE A 245
 None
 0.70A 4acbC-4pq0A:
undetectable		 4acbC-4pq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 450
ALA A 451
PHE A 388
LEU A 410
LEU A 441
 None
 1.25A 4kykA-4pq0A:
undetectable
4kykB-4pq0A:
undetectable		 4kykA-4pq0A:
20.82
4kykB-4pq0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 253
LEU A 316
VAL A 248
TYR A 257
LEU A 277
 None
 1.46A 4puoA-4pq0A:
2.3		 4puoA-4pq0A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 470
ILE A 412
PHE A 414
ALA A 401
ALA A 383
 None
 1.10A 5vc0A-4pq0A:
undetectable		 5vc0A-4pq0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 6 THR A 272
GLN A 308
TYR A 275
TYR A 257
 None
 1.27A 6ag0A-4pq0A:
undetectable		 6ag0A-4pq0A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4pq0 FACT COMPLEX SUBUNIT
POB3
(Saccharomyces
cerevisiae) 		4 / 6 THR A 272
GLN A 308
TYR A 275
TYR A 257
 None
 1.25A 6ag0C-4pq0A:
undetectable		 6ag0C-4pq0A:
16.04