SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 9 LEU A 147
LEU A 131
VAL A 111
LEU A 118
PHE A 136
 None
 1.26A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 9 LEU A 171
LEU A 155
VAL A 135
LEU A 142
PHE A 160
 None
 1.28A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 9 LEU A 195
LEU A 179
VAL A 159
LEU A 166
PHE A 184
 None
 1.24A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 9 LEU A 219
LEU A 203
VAL A 183
LEU A 190
PHE A 208
 None
 1.23A 1tbfA-4pq8A:
undetectable		 1tbfA-4pq8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		4 / 6 ASN A  71
ASN A  48
ILE A  10
GLN A  44
 None
 1.26A 2hkkA-4pq8A:
undetectable		 2hkkA-4pq8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 12 LEU A  97
GLY A  95
LEU A  88
SER A 100
GLY A  78
 None
 1.16A 2vmyB-4pq8A:
undetectable		 2vmyB-4pq8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 12 LEU A 187
LEU A 152
PHE A 160
PHE A 136
LEU A 107
 None
 1.22A 5iepA-4pq8A:
undetectable		 5iepA-4pq8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		4 / 4 ASN A  80
LEU A  82
SER A 100
LEU A  97
 None
 1.13A 5kb5A-4pq8A:
undetectable		 5kb5A-4pq8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 12 LEU A 131
ARG A 162
GLY A 158
GLU A 137
GLY A 134
 None
 1.22A 5o4yD-4pq8A:
undetectable
5o4yE-4pq8A:
undetectable		 5o4yD-4pq8A:
7.14
5o4yE-4pq8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 12 LEU A  33
LEU A  69
PRO A  70
PHE A  20
THR A  14
 None
 1.27A 6debB-4pq8A:
undetectable		 6debB-4pq8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4pq8 DESIGNED PROTEIN
OR465
(synthetic
construct) 		5 / 12 ASN A 126
ASN A 150
LEU A 123
ASN A 122
GLY A  79
 None
None
None
CL  A 301 (-4.3A)
None
 1.14A 6dwnA-4pq8A:
undetectable		 6dwnA-4pq8A:
14.61