SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		3 / 3 LYS A  30
ASP A 313
ASP A 309
 None
 0.96A 2br4D-4pqgA:
3.2		 2br4D-4pqgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 7 ILE A 276
GLN A 265
ARG A  24
ASP A 219
 None
 0.75A 2qqcB-4pqgA:
undetectable
2qqcC-4pqgA:
undetectable		 2qqcB-4pqgA:
13.74
2qqcC-4pqgA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 7 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 0.72A 2qqcA-4pqgA:
undetectable
2qqcF-4pqgA:
undetectable		 2qqcA-4pqgA:
7.85
2qqcF-4pqgA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 7 ILE A 276
GLN A 265
ARG A  24
ASP A 219
 None
 0.76A 2qqcD-4pqgA:
undetectable
2qqcE-4pqgA:
undetectable		 2qqcD-4pqgA:
13.74
2qqcE-4pqgA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 7 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 0.77A 2qqcG-4pqgA:
undetectable
2qqcJ-4pqgA:
undetectable		 2qqcG-4pqgA:
7.85
2qqcJ-4pqgA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 7 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 0.72A 2qqcI-4pqgA:
undetectable
2qqcL-4pqgA:
undetectable		 2qqcI-4pqgA:
7.85
2qqcL-4pqgA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 5 ILE A 489
PHE A  28
VAL A 228
PHE A 274
 None
 1.09A 2ygnA-4pqgA:
undetectable		 2ygnA-4pqgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 4 GLN A  61
PHE A  37
TYR A   4
LEU A  51
 None
 1.44A 3keeC-4pqgA:
0.0		 3keeC-4pqgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 6 VAL A 285
TYR A 427
TYR A 246
GLU A 248
 None
 1.15A 3q5sA-4pqgA:
0.0		 3q5sA-4pqgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 6 LYS A 460
ILE A 421
VAL A 396
LEU A 323
 None
 0.99A 4em2A-4pqgA:
undetectable		 4em2A-4pqgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 7 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 UDP  A 601 (-3.8A)
UDP  A 601 ( 3.0A)
None
None
 1.09A 4g0vA-4pqgA:
2.6		 4g0vA-4pqgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 6 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 UDP  A 601 (-3.8A)
UDP  A 601 ( 3.0A)
None
None
 1.20A 4g0vB-4pqgA:
3.2		 4g0vB-4pqgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 5 VAL A 396
LEU A 464
ILE A 421
LEU A 420
 None
 0.81A 4mghA-4pqgA:
undetectable		 4mghA-4pqgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		3 / 3 THR A 222
ASP A  41
GLU A  18
 None
 0.86A 5fa8A-4pqgA:
5.6		 5fa8A-4pqgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		5 / 9 ILE A 379
ILE A 356
VAL A 342
TYR A 397
ILE A 324
 None
 1.46A 5mvnB-4pqgA:
undetectable		 5mvnB-4pqgA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		5 / 10 ILE A 379
ILE A 356
VAL A 342
TYR A 397
ILE A 324
 None
 1.48A 5mvnD-4pqgA:
undetectable		 5mvnD-4pqgA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		5 / 12 VAL A  17
ARG A 328
TYR A 246
SER A 247
GLU A 332
 NAG  A 602 (-4.6A)
UDP  A 601 (-3.8A)
None
None
NAG  A 602 ( 3.9A)
 1.39A 5v1tA-4pqgA:
2.0		 5v1tA-4pqgA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		5 / 10 GLY A  16
HIS A 242
LYS A 333
GLU A 404
GLY A 407
 UDP  A 601 ( 3.0A)
NAG  A 602 (-3.9A)
UDP  A 601 (-2.8A)
NAG  A 602 (-3.6A)
UDP  A 601 ( 3.4A)
 0.67A 5vncC-4pqgA:
18.2		 5vncC-4pqgA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		5 / 12 LEU A 237
GLY A 225
GLN A 198
LEU A  65
ILE A   6
 None
 1.13A 5y2tA-4pqgA:
undetectable		 5y2tA-4pqgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		4 / 5 ARG A  24
ALA A  25
GLN A  21
ILE A  55
 None
 1.33A 6f6sA-4pqgA:
undetectable
6f6sB-4pqgA:
undetectable		 6f6sA-4pqgA:
10.92
6f6sB-4pqgA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4pqg GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
pneumoniae) 		6 / 12 GLU A  18
GLY A  16
HIS A 242
ARG A 328
GLU A 404
GLY A 407
 None
UDP  A 601 ( 3.0A)
NAG  A 602 (-3.9A)
UDP  A 601 (-3.8A)
NAG  A 602 (-3.6A)
UDP  A 601 ( 3.4A)
 0.76A 6gngA-4pqgA:
17.3		 6gngA-4pqgA:
23.32