SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		5 / 12 GLY A 105
LYS A  49
ASP A 160
GLY A 166
PRO A 110
 None
 1.06A 1sqfA-4pqhA:
undetectable		 1sqfA-4pqhA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		5 / 12 LEU A 122
PHE A 164
ILE A 179
ILE A 194
TYR A 175
 None
 1.47A 2efjA-4pqhA:
undetectable		 2efjA-4pqhA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		5 / 11 ILE A  44
THR A 217
ASN A 215
GLN A 216
LEU A  82
 None
 1.31A 2ft9A-4pqhA:
undetectable		 2ft9A-4pqhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		4 / 7 ASP A 172
VAL A 171
ALA A 119
PRO A 162
 None
 0.92A 2q6oA-4pqhA:
undetectable		 2q6oA-4pqhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		4 / 6 ARG A  41
PRO A  80
GLU A  91
SER A  92
 None
GSH  A 300 (-4.1A)
GSH  A 300 (-3.0A)
GSH  A 300 (-2.6A)
 0.36A 3vlnA-4pqhA:
22.8		 3vlnA-4pqhA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		3 / 3 GLY A 161
PRO A 162
ALA A 203
 None
 0.42A 4qn9B-4pqhA:
undetectable		 4qn9B-4pqhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		4 / 4 ILE A  44
ARG A 181
TYR A 214
GLU A 180
 None
 1.42A 4zzbD-4pqhA:
undetectable		 4zzbD-4pqhA:
21.94