SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		4 / 4 LYS A 121
LEU A 114
ALA A 124
LEU A 177
 None
 1.14A 1f86A-4pqiA:
undetectable		 1f86A-4pqiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		4 / 4 LYS A 121
LEU A 114
ALA A 124
LEU A 177
 None
 1.02A 1f86B-4pqiA:
undetectable		 1f86B-4pqiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 GLU A 213
ASN A 216
ASN A 190
ILE A 201
ASP A 200
 None
 1.40A 1q8jA-4pqiA:
undetectable		 1q8jA-4pqiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		4 / 7 ASP A 179
VAL A 178
ALA A 124
PRO A 168
 None
 0.99A 2q6oA-4pqiA:
undetectable		 2q6oA-4pqiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		4 / 7 LEU A 189
ALA A 153
GLY A 151
PHE A 192
 None
 0.92A 2wq5A-4pqiA:
undetectable		 2wq5A-4pqiA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 6 TYR A  79
GLY A  95
THR A  94
LEU A  87
GLU A  96
 None
None
None
None
GSH  A 301 (-3.2A)
 1.48A 3ps9A-4pqiA:
undetectable		 3ps9A-4pqiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 PHE A  43
CYH A  41
THR A  40
TYR A 235
TYR A 139
 GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
None
 1.29A 3sp6A-4pqiA:
undetectable		 3sp6A-4pqiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 LEU A  35
PHE A  43
CYH A  41
THR A  40
TYR A 139
 None
GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
 0.99A 3sp9A-4pqiA:
undetectable		 3sp9A-4pqiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 LEU A  35
PHE A  43
CYH A  41
THR A  40
TYR A 139
 None
GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
 0.99A 3sp9B-4pqiA:
undetectable		 3sp9B-4pqiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 6 PHE A  43
ARG A  46
PRO A  85
GLU A  96
SER A  97
 GSH  A 301 (-3.8A)
None
GSH  A 301 (-4.5A)
GSH  A 301 (-3.2A)
GSH  A 301 (-2.7A)
 0.36A 3vlnA-4pqiA:
24.1		 3vlnA-4pqiA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 ALA A   4
ILE A  49
LYS A 222
ALA A 220
ILE A 183
 None
 0.99A 4o2bD-4pqiA:
undetectable		 4o2bD-4pqiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		4 / 6 ARG A 205
ALA A 150
ASP A 155
LEU A 146
 None
 1.14A 4ot2A-4pqiA:
2.6		 4ot2A-4pqiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		3 / 3 GLY A 167
PRO A 168
ALA A 210
 CA  A 302 (-4.6A)
None
None
 0.56A 4qn9B-4pqiA:
undetectable		 4qn9B-4pqiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		4 / 4 ILE A  49
ARG A 188
TYR A 221
GLU A 187
 None
 1.33A 4zzbD-4pqiA:
3.4		 4zzbD-4pqiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 ALA A   4
ILE A  49
LYS A 222
ALA A 220
ILE A 183
 None
 0.91A 5eypB-4pqiA:
undetectable		 5eypB-4pqiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 ALA A   4
ILE A  49
LYS A 222
ALA A 220
ILE A 183
 None
 1.02A 5xiwB-4pqiA:
undetectable		 5xiwB-4pqiA:
14.11