SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 214
SER A 211
ARG A 181
THR A 187
 None
None
PO4  A 401 (-2.7A)
PO4  A 401 (-3.5A)
 1.14A 2f78B-4pqjA:
14.3		 2f78B-4pqjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 306
ILE A 230
GLY A 229
PHE A 128
 None
 0.95A 2vctD-4pqjA:
undetectable		 2vctD-4pqjA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 271
SER A 294
THR A 296
VAL A 301
ALA A 121
 None
 1.19A 2x2iA-4pqjA:
undetectable		 2x2iA-4pqjA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 271
SER A 294
THR A 296
VAL A 301
ALA A 121
 None
 1.15A 2x2iC-4pqjA:
undetectable		 2x2iC-4pqjA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 THR A 187
LEU A 125
VAL A 214
VAL A 215
 PO4  A 401 (-3.5A)
None
None
None
 1.00A 2z97A-4pqjA:
undetectable		 2z97A-4pqjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 THR A 139
ILE A 146
LEU A 165
ILE A 135
VAL A 218
 None
 1.26A 3a51A-4pqjA:
undetectable		 3a51A-4pqjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 225
ILE A 230
LEU A 178
PHE A 179
 None
 0.74A 3adsA-4pqjA:
undetectable		 3adsA-4pqjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 225
ILE A 230
LEU A 178
PHE A 179
 None
 0.73A 3adxA-4pqjA:
undetectable		 3adxA-4pqjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASN A  53
GLY A  47
THR A  80
ILE A  73
THR A  56
 None
 1.29A 3iv6A-4pqjA:
undetectable		 3iv6A-4pqjA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 SER A 185
GLY A 186
THR A 187
 PO4  A 401 (-2.6A)
PO4  A 401 (-3.4A)
PO4  A 401 (-3.5A)
 0.14A 3k9wA-4pqjA:
undetectable		 3k9wA-4pqjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 286
LYS A 290
GLN A 287
LEU A 281
 None
 1.20A 4xoyA-4pqjA:
undetectable		 4xoyA-4pqjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 201
ALA A 195
VAL A 143
ASP A 144
SER A 148
 None
 1.06A 4xp1A-4pqjA:
undetectable		 4xp1A-4pqjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 286
LYS A 290
GLN A 287
LEU A 281
 None
 1.15A 4xp3A-4pqjA:
undetectable		 4xp3A-4pqjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 205
LEU A 242
MET A 140
 None
 0.82A 5ikrA-4pqjA:
undetectable		 5ikrA-4pqjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 223
VAL A 176
GLY A 226
SER A 228
ARG A 181
 None
None
None
None
PO4  A 401 (-2.7A)
 1.34A 5lsaA-4pqjA:
undetectable		 5lsaA-4pqjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4pqj PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 133
GLY A 163
ILE A 135
VAL A 176
ILE A 225
 None
 0.97A 6ectA-4pqjA:
undetectable		 6ectA-4pqjA:
23.25