SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4pqo SORTING NEXIN-14
(Homo
sapiens) 		4 / 8 TYR A 617
PHE A 589
PHE A 682
LEU A 639
 None
 1.24A 1ea1A-4pqoA:
undetectable		 1ea1A-4pqoA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4pqo SORTING NEXIN-14
(Homo
sapiens) 		6 / 11 SER A 625
TYR A 663
LEU A 683
ALA A 680
THR A 628
LEU A 673
 None
 1.30A 1jinA-4pqoA:
undetectable		 1jinA-4pqoA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4pqo SORTING NEXIN-14
(Homo
sapiens) 		5 / 10 ALA A 680
LEU A 679
LEU A 668
VAL A 593
ILE A 567
 None
 1.06A 5v02B-4pqoA:
undetectable
5v02R-4pqoA:
undetectable		 5v02B-4pqoA:
19.23
5v02R-4pqoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pqo SORTING NEXIN-14
(Homo
sapiens) 		4 / 5 ILE A 591
LEU A 683
ARG A 616
LEU A 623
 None
 0.91A 6nmpN-4pqoA:
undetectable
6nmpW-4pqoA:
undetectable		 6nmpN-4pqoA:
11.11
6nmpW-4pqoA:
18.60