SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IMA_D_ADND604_1 (PYRUVATE KINASE)	4pqx	UNCHARACTERIZED PROTEIN (Bacteroides caccae)	3 / 3	ARG A 190 GLU A 121 ASN A 166	EDO A 301 ( 4.1A) EDO A 301 (-4.0A) EDO A 301 ( 4.0A)	0.87A	4imaD-4pqxA: undetectable	4imaD-4pqxA: 17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FLC_C_RAPC999_1 (SERINE/THREONINE-PRO TEIN KINASE MTOR FKBP)	4pqx	UNCHARACTERIZED PROTEIN (Bacteroides caccae)	4 / 8	SER A 66 GLY A 70 TYR A 52 PHE A 62	None	0.92A	5flcB-4pqxA: undetectable	5flcB-4pqxA: 10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FLC_G_RAPG999_1 (SERINE/THREONINE-PRO TEIN KINASE MTOR FKBP)	4pqx	UNCHARACTERIZED PROTEIN (Bacteroides caccae)	4 / 8	SER A 66 GLY A 70 TYR A 52 PHE A 62	None	0.92A	5flcF-4pqxA: undetectable	5flcF-4pqxA: 10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_B_RCXB601_2 (PROSTAGLANDIN G/H SYNTHASE 2)	4pqx	UNCHARACTERIZED PROTEIN (Bacteroides caccae)	4 / 4	LEU A 161 ARG A 190 ILE A 129 PHE A 189	None EDO A 301 ( 4.1A) None None	1.28A	5kirB-4pqxA: undetectable	5kirB-4pqxA: 15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D8P_A_ACTA816_0 (UNCHARACTERIZED PROTEIN)	4pqx	UNCHARACTERIZED PROTEIN (Bacteroides caccae)	3 / 3	ARG A 228 ARG A 190 ASP A 126	GOL A 308 (-3.0A) EDO A 301 ( 4.1A) None	0.74A	6d8pA-4pqxA: undetectable	6d8pA-4pqxA: 14.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4IMA_D_ADND604_1","PYRUVATE KINASE","4pqx","UNCHARACTERIZED PROTEIN","Bacteroides caccae",3,"ARG A 190;GLU A 121;ASN A 166","EDO A 301 ( 4.1A);EDO A 301 (-4.0A);EDO A 301 ( 4.0A)","0.87A","4imaD-4pqxA:undetectable","4imaD-4pqxA:17.71"],["5FLC_C_RAPC999_1","SERINE\/THREONINE-PROTEIN KINASE MTOR;FKBP","4pqx","UNCHARACTERIZED PROTEIN","Bacteroides caccae",4,"SER A  66;GLY A  70;TYR A  52;PHE A  62","None","0.92A","5flcB-4pqxA:undetectable","5flcB-4pqxA:10.57"],["5FLC_G_RAPG999_1","SERINE\/THREONINE-PROTEIN KINASE MTOR;FKBP","4pqx","UNCHARACTERIZED PROTEIN","Bacteroides caccae",4,"SER A  66;GLY A  70;TYR A  52;PHE A  62","None","0.92A","5flcF-4pqxA:undetectable","5flcF-4pqxA:10.57"],["5KIR_B_RCXB601_2","PROSTAGLANDIN G\/H SYNTHASE 2","4pqx","UNCHARACTERIZED PROTEIN","Bacteroides caccae",4,"LEU A 161;ARG A 190;ILE A 129;PHE A 189","None;EDO A 301 ( 4.1A);None;None","1.28A","5kirB-4pqxA:undetectable","5kirB-4pqxA:15.64"],["6D8P_A_ACTA816_0","UNCHARACTERIZED PROTEIN","4pqx","UNCHARACTERIZED PROTEIN","Bacteroides caccae",3,"ARG A 228;ARG A 190;ASP A 126","GOL A 308 (-3.0A);EDO A 301 ( 4.1A);None","0.74A","6d8pA-4pqxA:undetectable","6d8pA-4pqxA:14.14"]]