SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4prk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		4 / 4 ILE A 201
MET A 224
VAL A 239
GLY A 150
 None
 1.34A 1e06B-4prkA:
undetectable		 1e06B-4prkA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ILE A 152
GLY A 153
GLY A 155
VAL A 177
PRO A 207
 None
 0.99A 1nv8A-4prkA:
5.9		 1nv8A-4prkA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ILE A 152
GLY A 153
GLY A 155
VAL A 177
PRO A 207
 None
 0.98A 1nv8B-4prkA:
5.3		 1nv8B-4prkA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ILE A 229
ILE A 253
ALA A 254
LEU A 117
PHE A 221
 None
 1.24A 1xzxX-4prkA:
undetectable		 1xzxX-4prkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ILE A 253
ALA A 254
LEU A 117
LEU A 258
PHE A 221
 None
 1.21A 1xzxX-4prkA:
undetectable		 1xzxX-4prkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		4 / 5 LEU A 230
MET A 215
LEU A 238
HIS A 205
 None
 1.30A 2jfaA-4prkA:
undetectable		 2jfaA-4prkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		4 / 7 ILE A 157
LEU A 151
GLY A 153
TYR A 189
 None
 0.89A 2tsrA-4prkA:
undetectable		 2tsrA-4prkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 10 LEU A  65
VAL A  48
GLY A  47
GLY A  74
THR A  94
 None
 1.25A 2wd9C-4prkA:
4.5		 2wd9C-4prkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 THR A 212
PHE A 221
ILE A 202
ARG A 235
LEU A 204
 None
 0.92A 3iv6C-4prkA:
5.1		 3iv6C-4prkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 THR A 212
PHE A 221
ILE A 202
ARG A 235
LEU A 204
 None
 1.06A 3iv6D-4prkA:
5.8		 3iv6D-4prkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		6 / 12 LEU A 238
ILE A 216
VAL A 290
ASN A 232
LEU A 258
VAL A 292
 None
 1.35A 4gc9A-4prkA:
3.9		 4gc9A-4prkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ALA A 255
LEU A 258
ILE A 216
LEU A 204
ILE A 202
 None
 1.11A 4nx6A-4prkA:
undetectable		 4nx6A-4prkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ALA A 255
LEU A 258
ILE A 216
LEU A 204
ILE A 202
 None
 1.10A 4nx7A-4prkA:
undetectable		 4nx7A-4prkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ASN A 180
VAL A 154
GLY A 155
SER A 159
LEU A 187
 None
 1.24A 4ot2A-4prkA:
undetectable		 4ot2A-4prkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		4 / 8 ALA A 110
ILE A 231
LEU A 151
ALA A 170
 None
 0.62A 4wboB-4prkA:
undetectable		 4wboB-4prkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		4 / 7 VAL A  48
LEU A  50
ALA A   4
LEU A  65
 None
 0.57A 5jq7A-4prkA:
undetectable		 5jq7A-4prkA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE
(Lactobacillus
jensenii) 		5 / 12 ASN A 180
VAL A 154
GLY A 155
SER A 159
LEU A 187
 None
 1.27A 6ci6A-4prkA:
undetectable		 6ci6A-4prkA:
14.56