SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4psd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 VAL A 100
GLY A 101
ILE A 225
ASP A 216
HIS A 213
 None
 1.21A 1kxhA-4psdA:
undetectable		 1kxhA-4psdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		4 / 6 GLY A  89
SER A 164
ILE A 225
HIS A 229
 None
 0.81A 1yajF-4psdA:
5.1		 1yajF-4psdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		4 / 4 GLY A  89
SER A 164
ILE A 225
HIS A 229
 None
 0.79A 1yajJ-4psdA:
4.8		 1yajJ-4psdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLY A 101
GLY A  97
ASN A  95
ALA A 233
ALA A 236
 None
 1.00A 3mteB-4psdA:
undetectable		 3mteB-4psdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLY A 101
GLY A  97
ASN A  95
ALA A 233
ALA A 236
 None
 1.00A 3p2kA-4psdA:
undetectable		 3p2kA-4psdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLY A  89
GLY A 161
ALA A  87
ALA A 173
SER A 175
 None
 0.90A 3sudA-4psdA:
undetectable		 3sudA-4psdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLY A  89
GLY A 162
ALA A  87
ALA A 173
SER A 175
 None
 1.01A 3sudA-4psdA:
undetectable		 3sudA-4psdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		4 / 7 PHE A 105
PHE A 104
GLY A 161
PHE A 191
 None
 1.14A 3vnsA-4psdA:
4.2		 3vnsA-4psdA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLY A  94
GLY A  61
GLY A  97
VAL A  44
ASP A  63
 None
 0.93A 4ctjC-4psdA:
undetectable		 4ctjC-4psdA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		4 / 8 SER A 167
ASP A 193
VAL A 188
THR A 208
 None
 1.13A 4lnwA-4psdA:
undetectable		 4lnwA-4psdA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 10 GLY A 162
LEU A 209
ALA A 239
ASP A 235
ALA A 233
 None
 1.28A 4wnuD-4psdA:
undetectable		 4wnuD-4psdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 HIS A 249
VAL A 159
LEU A 158
GLY A 118
LEU A 108
 None
 1.01A 5kirA-4psdA:
undetectable		 5kirA-4psdA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 ILE A  58
ILE A  51
PHE A 131
LEU A 230
VAL A 100
 None
 1.44A 5uanB-4psdA:
undetectable		 5uanB-4psdA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLU A  75
GLY A 101
VAL A 149
LEU A 158
GLY A 118
 None
 1.04A 5vooA-4psdA:
undetectable		 5vooA-4psdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLU A  75
GLY A 101
VAL A 149
LEU A 158
GLY A 118
 None
 0.97A 5vooB-4psdA:
undetectable		 5vooB-4psdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLU A  75
GLY A 101
VAL A 149
LEU A 158
GLY A 118
 None
 1.02A 5vooC-4psdA:
undetectable		 5vooC-4psdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4psd CARBOHYDRATE
ESTERASE FAMILY 5
(Trichoderma
reesei) 		5 / 12 GLU A  75
GLY A 101
VAL A 149
LEU A 158
GLY A 118
 None
 1.05A 5vopA-4psdA:
undetectable		 5vopA-4psdA:
22.51