SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4psj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4psj OR464
(synthetic
construct) 		4 / 7 LEU A  94
LEU A 115
SER A 138
SER A 114
 None
 0.89A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4psj OR464
(synthetic
construct) 		4 / 7 LEU A 118
LEU A 139
SER A 162
SER A 138
 None
 0.99A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4psj OR464
(synthetic
construct) 		4 / 7 LEU A 142
LEU A 163
SER A 186
SER A 162
 None
 0.97A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4psj OR464
(synthetic
construct) 		4 / 7 LEU A 166
LEU A 187
SER A 210
SER A 186
 None
 1.03A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4psj OR464
(synthetic
construct) 		4 / 7 LEU A 190
LEU A 211
SER A 234
SER A 210
 None
 1.01A 1dvxA-4psjA:
undetectable		 1dvxA-4psjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4psj OR464
(synthetic
construct) 		5 / 12 PHE A 136
ILE A 104
ASN A 122
SER A 148
LEU A 131
 None
 1.05A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4psj OR464
(synthetic
construct) 		5 / 12 PHE A 160
ILE A 128
ASN A 146
SER A 172
LEU A 155
 None
 1.04A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4psj OR464
(synthetic
construct) 		5 / 12 PHE A 184
ILE A 152
ASN A 170
SER A 196
LEU A 179
 None
 1.05A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4psj OR464
(synthetic
construct) 		5 / 12 PHE A 208
ILE A 176
ASN A 194
SER A 220
LEU A 203
 None
 1.08A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4psj OR464
(synthetic
construct) 		4 / 6 ASN A  71
ASN A  48
ILE A  10
GLN A  44
 None
 1.26A 2hkkA-4psjA:
undetectable		 2hkkA-4psjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4psj OR464
(synthetic
construct) 		5 / 12 LEU A  97
GLY A  95
LEU A  88
SER A 100
GLY A  78
 None
 1.17A 2vmyB-4psjA:
undetectable		 2vmyB-4psjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4psj OR464
(synthetic
construct) 		3 / 3 GLU A 113
GLY A 110
SER A 138
 None
 0.69A 4b53B-4psjA:
undetectable		 4b53B-4psjA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4psj OR464
(synthetic
construct) 		4 / 4 ASN A  80
VAL A  63
THR A  28
ILE A  29
 None
 1.38A 4retA-4psjA:
undetectable		 4retA-4psjA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4psj OR464
(synthetic
construct) 		4 / 4 ASN A  80
VAL A  63
THR A  28
ILE A  29
 None
 1.38A 4retC-4psjA:
undetectable		 4retC-4psjA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4psj OR464
(synthetic
construct) 		4 / 4 ASN A  80
LEU A  82
SER A 100
LEU A  97
 None
 1.13A 5kb5A-4psjA:
undetectable		 5kb5A-4psjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4psj OR464
(synthetic
construct) 		5 / 12 LEU A  33
LEU A  69
PRO A  70
PHE A  20
THR A  14
 None
 1.25A 6debB-4psjA:
undetectable		 6debB-4psjA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4psj OR464
(synthetic
construct) 		5 / 12 ASN A 126
ASN A 150
LEU A 123
ASN A 122
GLY A  79
 None
 1.09A 6dwnA-4psjA:
undetectable		 6dwnA-4psjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4psj OR464
(synthetic
construct) 		4 / 7 LEU A 262
LEU A 241
LEU A 238
LEU A 203
 None
 0.71A 6g9bA-4psjA:
undetectable
6g9bB-4psjA:
undetectable		 6g9bA-4psjA:
14.13
6g9bB-4psjA:
14.62