SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4psn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4psn SSDNA BINDING
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 126
THR A 129
VAL A 217
GLY A 161
LEU A 153
 None
 1.00A 2cbrA-4psnA:
2.3		 2cbrA-4psnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4psn SSDNA BINDING
PROTEIN
(Aeropyrum
pernix) 		5 / 9 GLY A  13
ALA A  12
ALA A  61
ASP A  65
LEU A  64
 None
 1.40A 3ur0C-4psnA:
undetectable		 3ur0C-4psnA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4psn SSDNA BINDING
PROTEIN
(Aeropyrum
pernix) 		5 / 12 PHE A  82
ALA A  43
ARG A  19
TYR A  14
LEU A  87
 None
 1.48A 4qzuB-4psnA:
2.3		 4qzuB-4psnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4psn SSDNA BINDING
PROTEIN
(Aeropyrum
pernix) 		4 / 7 LEU A 148
VAL A 210
ILE A 119
VAL A 163
 None
 0.70A 5jh7C-4psnA:
undetectable		 5jh7C-4psnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4psn SSDNA BINDING
PROTEIN
(Aeropyrum
pernix) 		5 / 12 TYR A  14
ILE A  69
GLY A  45
ALA A  44
LEU A  22
 None
 1.03A 5zwrA-4psnA:
undetectable		 5zwrA-4psnA:
22.56