SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		5 / 12 ILE P 269
LEU P 266
HIS P 177
LEU P 141
ILE P 129
 None
 1.06A 1fmlB-4pt2P:
undetectable		 1fmlB-4pt2P:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		5 / 10 ALA P 164
GLU P 167
LEU P 278
LEU P 152
LEU P 189
 None
 1.49A 3erdB-4pt2P:
undetectable		 3erdB-4pt2P:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		5 / 11 THR P  23
GLN P  26
ALA P 113
GLY P 116
ALA P 118
 None
 1.33A 3mg0H-4pt2P:
undetectable
3mg0I-4pt2P:
undetectable		 3mg0H-4pt2P:
22.71
3mg0I-4pt2P:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		3 / 3 ARG P  29
GLU P  22
ARG P  30
 None
 0.94A 4mwvA-4pt2P:
undetectable		 4mwvA-4pt2P:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		4 / 5 TYR P  53
GLY P 137
ASP P 133
VAL P 228
 None
 1.11A 4nkvD-4pt2P:
undetectable		 4nkvD-4pt2P:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		4 / 7 VAL P 216
ILE P 165
HIS P 194
LEU P 203
 None
 1.16A 4xo7B-4pt2P:
undetectable		 4xo7B-4pt2P:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		5 / 12 GLY P 179
LEU P 141
HIS P 177
THR P 232
MET P 237
 None
 1.31A 4ze1A-4pt2P:
undetectable		 4ze1A-4pt2P:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		5 / 11 THR P  23
GLN P  26
ALA P 113
GLY P 116
ALA P 118
 None
 1.24A 5bxnV-4pt2P:
undetectable
5bxnW-4pt2P:
undetectable		 5bxnV-4pt2P:
22.62
5bxnW-4pt2P:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4pt2 ENCAPSULIN PROTEIN
(Myxococcus
xanthus) 		5 / 12 THR P  23
GLN P  26
ALA P 113
GLY P 116
ALA P 118
 None
 1.36A 5l5zH-4pt2P:
undetectable
5l5zI-4pt2P:
undetectable		 5l5zH-4pt2P:
22.62
5l5zI-4pt2P:
22.97