SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ptf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G50_A_ESTA600_1 (ESTROGEN RECEPTOR)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 11	LEU A 874 GLU A 559 LEU A 561 ILE A 882 LEU A 955	None	1.25A	1g50A-4ptfA: undetectable	1g50A-4ptfA: 12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDT_A_VIAA1000_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	TYR A 525 TYR A 245 ILE A 170 ALA A 524 PHE A 140	None	1.27A	1udtA-4ptfA: undetectable	1udtA-4ptfA: 14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_B_715B801_2 (DIPEPTIDYL PEPTIDASE IV)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	PHE A 119 TYR A 249 TYR A 135	None	0.93A	1x70B-4ptfA: undetectable	1x70B-4ptfA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CC8_A_RBFA1067_1 (VNG1446H)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	PHE A 494 VAL A 261 TRP A 78	None	0.78A	2cc8A-4ptfA: undetectable	2cc8A-4ptfA: 5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CCB_A_RBFA1067_1 (VNG1446H)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	PHE A 494 VAL A 261 TRP A 78	None	0.78A	2ccbA-4ptfA: undetectable	2ccbA-4ptfA: 5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J7X_A_ESTA1454_1 (ESTROGEN RECEPTOR BETA)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	LEU A 874 GLU A 559 LEU A 561 ILE A 882 LEU A 955	None	1.29A	2j7xA-4ptfA: undetectable	2j7xA-4ptfA: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD5_A_CHDA701_0 (FERROCHELATASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 8	LEU A 978 PRO A 433 SER A 436 GLY A 983	None	0.86A	2qd5A-4ptfA: undetectable	2qd5A-4ptfA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_A_HSMA145_1 (D7R4 PROTEIN)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	ILE A 735 ARG A 738 PHE A 709 GLU A 707	None	0.77A	2qebA-4ptfA: undetectable	2qebA-4ptfA: 8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_B_HSMB145_1 (D7R4 PROTEIN)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	ILE A 735 ARG A 738 PHE A 709 GLU A 707	None	0.78A	2qebB-4ptfA: undetectable	2qebB-4ptfA: 8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VX9_A_RBFA1064_1 (DODECIN)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	PHE A 494 VAL A 261 TRP A 78	None	0.77A	2vx9A-4ptfA: undetectable	2vx9A-4ptfA: 6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_A_EPAA1_2 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	CYH A 497 THR A 498 LEU A 79 MET A 420 TYR A 485	None	1.33A	3gwxA-4ptfA: undetectable	3gwxA-4ptfA: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H0A_A_9RAA500_2 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	ILE A 879 PHE A 944 HIS A 557	None	0.74A	3h0aA-4ptfA: undetectable	3h0aA-4ptfA: 11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCN_A_CHDA3_0 (FERROCHELATASE, MITOCHONDRIAL)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	LEU A 978 PRO A 433 SER A 436 GLY A 983	None	0.95A	3hcnA-4ptfA: undetectable	3hcnA-4ptfA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCR_B_CHDB924_0 (FERROCHELATASE, MITOCHONDRIAL)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	LEU A 978 PRO A 433 SER A 436 GLY A 983	None	0.90A	3hcrB-4ptfA: undetectable	3hcrB-4ptfA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IB0_A_DIFA701_1 (LACTOTRANSFERRIN)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 4	PRO A 137 TYR A 135 GLY A 116 THR A 85	None	1.28A	3ib0A-4ptfA: undetectable	3ib0A-4ptfA: 14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB2_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	ASN A 828 PRO A 646 GLY A 854 ILE A 858 GLU A 559	DCP A1201 (-3.1A) None None None None	1.44A	3jb2A-4ptfA: undetectable	3jb2A-4ptfA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB2_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	MET A 398 PRO A 406 GLY A 379 ILE A 291 GLU A 292	None	0.98A	3jb2A-4ptfA: undetectable	3jb2A-4ptfA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KD5_E_PPFE914_1 (DNA POLYMERASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 5	ASP A 640 ARG A 781 LYS A 824 ASP A 877	CA A1203 (-2.6A) DCP A1201 (-2.8A) DCP A1201 (-2.7A) DCP A1201 (-2.7A)	0.49A	3kd5E-4ptfA: 20.8	3kd5E-4ptfA: 22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KM6_A_EAAA222_1 (GLUTATHIONE S-TRANSFERASE P)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 10	TYR A 55 VAL A 267 GLY A 74 VAL A 133 GLY A 271	None	1.23A	3km6A-4ptfA: undetectable	3km6A-4ptfA: 11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LTW_A_HLZA300_1 (ARYLAMINE N-ACETYLTRANSFERASE NAT)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 6	PHE A 121 TYR A 265 VAL A 117 PHE A 272	None	1.16A	3ltwA-4ptfA: undetectable	3ltwA-4ptfA: 13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3R_C_9PLC501_1 (CYTOCHROME P450 2A6)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 9	PHE A1003 PHE A1006 VAL A 565 PHE A 984 ILE A1157	None	1.37A	3t3rC-4ptfA: undetectable	3t3rC-4ptfA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AE1_A_NCAA1536_0 (DIPHTHERIA TOXIN)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 6	GLY A 564 TYR A 969 ALA A 563 GLU A 873	None	0.90A	4ae1A-4ptfA: undetectable	4ae1A-4ptfA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C8B_B_0LIB1000_2 (RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	TYR A 120 MET A 82 ILE A 500	None	0.88A	4c8bB-4ptfA: 2.4	4c8bB-4ptfA: 15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JQ4_B_IMNB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 10	TYR A 138 VAL A 251 ASN A 533 LEU A 530 LEU A 531	None	1.43A	4jq4B-4ptfA: undetectable	4jq4B-4ptfA: 14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_A_1LDA501_0 (CYTOSINE DEAMINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	HIS A 823 LEU A 515 PHE A 492 ILE A 493 LEU A 519	None	1.44A	4r88A-4ptfA: undetectable	4r88A-4ptfA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_B_1LDB501_0 (CYTOSINE DEAMINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	HIS A 823 LEU A 515 PHE A 492 ILE A 493 LEU A 519	None	1.46A	4r88B-4ptfA: undetectable	4r88B-4ptfA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_C_1LDC501_0 (CYTOSINE DEAMINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	HIS A 823 LEU A 515 PHE A 492 ILE A 493 LEU A 519	None	1.44A	4r88C-4ptfA: undetectable	4r88C-4ptfA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_D_1LDD501_0 (CYTOSINE DEAMINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	HIS A 823 LEU A 515 PHE A 492 ILE A 493 LEU A 519	None	1.44A	4r88D-4ptfA: undetectable	4r88D-4ptfA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_E_1LDE501_0 (CYTOSINE DEAMINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	HIS A 823 LEU A 515 PHE A 492 ILE A 493 LEU A 519	None	1.46A	4r88E-4ptfA: undetectable	4r88E-4ptfA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_F_1LDF502_0 (CYTOSINE DEAMINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	HIS A 823 LEU A 515 PHE A 492 ILE A 493 LEU A 519	None	1.43A	4r88F-4ptfA: undetectable	4r88F-4ptfA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V2Y_C_EF2C151_1 (CEREBLON ISOFORM 4)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	ASN A 503 PRO A 504 PHE A 494 TYR A 265	None	1.15A	4v2yC-4ptfA: undetectable	4v2yC-4ptfA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V2Z_C_Y70C151_1 (CEREBLON ISOFORM 4)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 8	ASN A 503 PRO A 504 PHE A 494 TYR A 265	None	1.18A	4v2zC-4ptfA: undetectable	4v2zC-4ptfA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V32_C_EF2C151_1 (CEREBLON ISOFORM 4)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	ASN A 503 PRO A 504 PHE A 494 PHE A 121	None	1.49A	4v32C-4ptfA: undetectable	4v32C-4ptfA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X3M_A_ADNA301_1 (RNA 2'-O RIBOSE METHYLTRANSFERASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 9	LEU A 515 GLY A 511 ILE A 493 MET A 420 THR A 507	None	1.46A	4x3mA-4ptfA: undetectable	4x3mA-4ptfA: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A1R_A_STRA600_1 (CYTOCHROME P450 3A4)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 5	PHE A 121 ASP A 123 PHE A 129 VAL A 267	None	1.10A	5a1rA-4ptfA: undetectable	5a1rA-4ptfA: 17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AMH_A_EF2A151_1 (CEREBLON ISOFORM 4)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	ASN A 503 PRO A 504 PHE A 494 TYR A 265	None	1.11A	5amhA-4ptfA: undetectable	5amhA-4ptfA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJC_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	PHE A 972 ALA A 970 LEU A 981 PHE A 984 ILE A1002	None	1.30A	5ljcA-4ptfA: undetectable	5ljcA-4ptfA: 7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MAF_A_XINA403_2 (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 5	LEU A1012 CYH A1015 LEU A1007 ASP A 569	None	1.46A	5mafA-4ptfA: undetectable	5mafA-4ptfA: 5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5D_A_SAMA306_1 (METHYLTRANSFERASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 7	LEU A 439 PHE A 377 ILE A 374 ASP A 290	None None None CA A1204 (-2.8A)	0.95A	5n5dA-4ptfA: undetectable	5n5dA-4ptfA: 11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OH1_C_9UQC202_0 (CEREBLON ISOFORM 4)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 8	ASN A 503 PRO A 504 PHE A 494 TYR A 265	None	1.49A	5oh1C-4ptfA: undetectable	5oh1C-4ptfA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TOA_A_ESTA601_1 (ESTROGEN RECEPTOR BETA)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	ALA A 524 LEU A 531 ARG A 252 LEU A 188 LEU A 175	None	1.04A	5toaA-4ptfA: undetectable	5toaA-4ptfA: 11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TT3_H_EZLH303_1 (ALPHA-CARBONIC ANHYDRASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 8	VAL A 426 LEU A 484 THR A 481 ALA A 480	None	0.82A	5tt3H-4ptfA: undetectable	5tt3H-4ptfA: 11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCV_A_1N1A404_2 (MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 5	VAL A 971 LEU A 872 CYH A 881 ASP A 947	None	1.11A	5vcvA-4ptfA: undetectable	5vcvA-4ptfA: 13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECF_I_DVAI3010_0 (VLM2 DODECADEPSIPEPTIDE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	3 / 3	PHE A 140 ARG A 252 ALA A 524	None	0.98A	6ecfB-4ptfA: undetectable	6ecfB-4ptfA: 13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GQI_A_ACTA604_0 (CYCLOHEXANONE MONOOXYGENASE FROM THERMOCRISPUM MUNICIPALE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	4 / 6	PRO A 532 TRP A 841 ILE A 529 GLU A 173	None	1.10A	6gqiA-4ptfA: undetectable	6gqiA-4ptfA: 18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_F_FFOF403_0 (THYMIDYLATE SYNTHASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 11	ILE A 857 ASN A 911 ASP A 640 GLY A 878 ALA A 642	None None CA A1203 (-2.6A) CA A1203 ( 4.4A) DCP A1201 ( 4.3A)	1.27A	6r2eF-4ptfA: undetectable	6r2eF-4ptfA: 13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_H_FFOH403_0 (THYMIDYLATE SYNTHASE)	4ptf	DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A (Saccharomyces cerevisiae)	5 / 12	ILE A 857 ASN A 911 ASP A 640 GLY A 878 ALA A 642	None None CA A1203 (-2.6A) CA A1203 ( 4.4A) DCP A1201 ( 4.3A)	1.26A	6r2eH-4ptfA: undetectable	6r2eH-4ptfA: 13.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1G50_A_ESTA600_1","ESTROGEN RECEPTOR","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"LEU A 874;GLU A 559;LEU A 561;ILE A 882;LEU A 955","None","1.25A","1g50A-4ptfA:undetectable","1g50A-4ptfA:12.05"],["1UDT_A_VIAA1000_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"TYR A 525;TYR A 245;ILE A 170;ALA A 524;PHE A 140","None","1.27A","1udtA-4ptfA:undetectable","1udtA-4ptfA:14.26"],["1X70_B_715B801_2","DIPEPTIDYL PEPTIDASE IV","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"PHE A 119;TYR A 249;TYR A 135","None","0.93A","1x70B-4ptfA:undetectable","1x70B-4ptfA:21.46"],["2CC8_A_RBFA1067_1","VNG1446H","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"PHE A 494;VAL A 261;TRP A  78","None","0.78A","2cc8A-4ptfA:undetectable","2cc8A-4ptfA:5.46"],["2CCB_A_RBFA1067_1","VNG1446H","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"PHE A 494;VAL A 261;TRP A  78","None","0.78A","2ccbA-4ptfA:undetectable","2ccbA-4ptfA:5.46"],["2J7X_A_ESTA1454_1","ESTROGEN RECEPTOR BETA","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"LEU A 874;GLU A 559;LEU A 561;ILE A 882;LEU A 955","None","1.29A","2j7xA-4ptfA:undetectable","2j7xA-4ptfA:12.56"],["2QD5_A_CHDA701_0","FERROCHELATASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"LEU A 978;PRO A 433;SER A 436;GLY A 983","None","0.86A","2qd5A-4ptfA:undetectable","2qd5A-4ptfA:14.70"],["2QEB_A_HSMA145_1","D7R4 PROTEIN","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ILE A 735;ARG A 738;PHE A 709;GLU A 707","None","0.77A","2qebA-4ptfA:undetectable","2qebA-4ptfA:8.91"],["2QEB_B_HSMB145_1","D7R4 PROTEIN","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ILE A 735;ARG A 738;PHE A 709;GLU A 707","None","0.78A","2qebB-4ptfA:undetectable","2qebB-4ptfA:8.91"],["2VX9_A_RBFA1064_1","DODECIN","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"PHE A 494;VAL A 261;TRP A  78","None","0.77A","2vx9A-4ptfA:undetectable","2vx9A-4ptfA:6.29"],["3GWX_A_EPAA1_2","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"CYH A 497;THR A 498;LEU A  79;MET A 420;TYR A 485","None","1.33A","3gwxA-4ptfA:undetectable","3gwxA-4ptfA:11.45"],["3H0A_A_9RAA500_2","RETINOIC ACID RECEPTOR RXR-ALPHA","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"ILE A 879;PHE A 944;HIS A 557","None","0.74A","3h0aA-4ptfA:undetectable","3h0aA-4ptfA:11.81"],["3HCN_A_CHDA3_0","FERROCHELATASE, MITOCHONDRIAL","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"LEU A 978;PRO A 433;SER A 436;GLY A 983","None","0.95A","3hcnA-4ptfA:undetectable","3hcnA-4ptfA:14.70"],["3HCR_B_CHDB924_0","FERROCHELATASE, MITOCHONDRIAL","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"LEU A 978;PRO A 433;SER A 436;GLY A 983","None","0.90A","3hcrB-4ptfA:undetectable","3hcrB-4ptfA:14.70"],["3IB0_A_DIFA701_1","LACTOTRANSFERRIN","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"PRO A 137;TYR A 135;GLY A 116;THR A  85","None","1.28A","3ib0A-4ptfA:undetectable","3ib0A-4ptfA:14.64"],["3JB2_A_SAMA1101_0","STRUCTURAL PROTEIN VP3","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"ASN A 828;PRO A 646;GLY A 854;ILE A 858;GLU A 559","DCP A1201 (-3.1A);None;None;None;None","1.44A","3jb2A-4ptfA:undetectable","3jb2A-4ptfA:22.37"],["3JB2_A_SAMA1101_0","STRUCTURAL PROTEIN VP3","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"MET A 398;PRO A 406;GLY A 379;ILE A 291;GLU A 292","None","0.98A","3jb2A-4ptfA:undetectable","3jb2A-4ptfA:22.37"],["3KD5_E_PPFE914_1","DNA POLYMERASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ASP A 640;ARG A 781;LYS A 824;ASP A 877"," CA A1203 (-2.6A);DCP A1201 (-2.8A);DCP A1201 (-2.7A);DCP A1201 (-2.7A)","0.49A","3kd5E-4ptfA:20.8","3kd5E-4ptfA:22.61"],["3KM6_A_EAAA222_1","GLUTATHIONE S-TRANSFERASE P","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"TYR A  55;VAL A 267;GLY A  74;VAL A 133;GLY A 271","None","1.23A","3km6A-4ptfA:undetectable","3km6A-4ptfA:11.44"],["3LTW_A_HLZA300_1","ARYLAMINE N-ACETYLTRANSFERASE NAT","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"PHE A 121;TYR A 265;VAL A 117;PHE A 272","None","1.16A","3ltwA-4ptfA:undetectable","3ltwA-4ptfA:13.37"],["3T3R_C_9PLC501_1","CYTOCHROME P450 2A6","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"PHE A1003;PHE A1006;VAL A 565;PHE A 984;ILE A1157","None","1.37A","3t3rC-4ptfA:undetectable","3t3rC-4ptfA:17.91"],["4AE1_A_NCAA1536_0","DIPHTHERIA TOXIN","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"GLY A 564;TYR A 969;ALA A 563;GLU A 873","None","0.90A","4ae1A-4ptfA:undetectable","4ae1A-4ptfA:undetectable"],["4C8B_B_0LIB1000_2","RECEPTOR-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 2","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"TYR A 120;MET A  82;ILE A 500","None","0.88A","4c8bB-4ptfA:2.4","4c8bB-4ptfA:15.30"],["4JQ4_B_IMNB401_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"TYR A 138;VAL A 251;ASN A 533;LEU A 530;LEU A 531","None","1.43A","4jq4B-4ptfA:undetectable","4jq4B-4ptfA:14.20"],["4R88_A_1LDA501_0","CYTOSINE DEAMINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"HIS A 823;LEU A 515;PHE A 492;ILE A 493;LEU A 519","None","1.44A","4r88A-4ptfA:undetectable","4r88A-4ptfA:17.15"],["4R88_B_1LDB501_0","CYTOSINE DEAMINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"HIS A 823;LEU A 515;PHE A 492;ILE A 493;LEU A 519","None","1.46A","4r88B-4ptfA:undetectable","4r88B-4ptfA:17.15"],["4R88_C_1LDC501_0","CYTOSINE DEAMINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"HIS A 823;LEU A 515;PHE A 492;ILE A 493;LEU A 519","None","1.44A","4r88C-4ptfA:undetectable","4r88C-4ptfA:17.15"],["4R88_D_1LDD501_0","CYTOSINE DEAMINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"HIS A 823;LEU A 515;PHE A 492;ILE A 493;LEU A 519","None","1.44A","4r88D-4ptfA:undetectable","4r88D-4ptfA:17.15"],["4R88_E_1LDE501_0","CYTOSINE DEAMINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"HIS A 823;LEU A 515;PHE A 492;ILE A 493;LEU A 519","None","1.46A","4r88E-4ptfA:undetectable","4r88E-4ptfA:17.15"],["4R88_F_1LDF502_0","CYTOSINE DEAMINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"HIS A 823;LEU A 515;PHE A 492;ILE A 493;LEU A 519","None","1.43A","4r88F-4ptfA:undetectable","4r88F-4ptfA:17.15"],["4V2Y_C_EF2C151_1","CEREBLON ISOFORM 4","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ASN A 503;PRO A 504;PHE A 494;TYR A 265","None","1.15A","4v2yC-4ptfA:undetectable","4v2yC-4ptfA:7.12"],["4V2Z_C_Y70C151_1","CEREBLON ISOFORM 4","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ASN A 503;PRO A 504;PHE A 494;TYR A 265","None","1.18A","4v2zC-4ptfA:undetectable","4v2zC-4ptfA:7.12"],["4V32_C_EF2C151_1","CEREBLON ISOFORM 4","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ASN A 503;PRO A 504;PHE A 494;PHE A 121","None","1.49A","4v32C-4ptfA:undetectable","4v32C-4ptfA:7.12"],["4X3M_A_ADNA301_1","RNA 2'-O RIBOSE METHYLTRANSFERASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"LEU A 515;GLY A 511;ILE A 493;MET A 420;THR A 507","None","1.46A","4x3mA-4ptfA:undetectable","4x3mA-4ptfA:12.53"],["5A1R_A_STRA600_1","CYTOCHROME P450 3A4","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"PHE A 121;ASP A 123;PHE A 129;VAL A 267","None","1.10A","5a1rA-4ptfA:undetectable","5a1rA-4ptfA:17.08"],["5AMH_A_EF2A151_1","CEREBLON ISOFORM 4","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ASN A 503;PRO A 504;PHE A 494;TYR A 265","None","1.11A","5amhA-4ptfA:undetectable","5amhA-4ptfA:7.12"],["5LJC_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"PHE A 972;ALA A 970;LEU A 981;PHE A 984;ILE A1002","None","1.30A","5ljcA-4ptfA:undetectable","5ljcA-4ptfA:7.97"],["5MAF_A_XINA403_2","MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"LEU A1012;CYH A1015;LEU A1007;ASP A 569","None","1.46A","5mafA-4ptfA:undetectable","5mafA-4ptfA:5.94"],["5N5D_A_SAMA306_1","METHYLTRANSFERASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"LEU A 439;PHE A 377;ILE A 374;ASP A 290","None;None;None; CA A1204 (-2.8A)","0.95A","5n5dA-4ptfA:undetectable","5n5dA-4ptfA:11.47"],["5OH1_C_9UQC202_0","CEREBLON ISOFORM 4","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"ASN A 503;PRO A 504;PHE A 494;TYR A 265","None","1.49A","5oh1C-4ptfA:undetectable","5oh1C-4ptfA:7.12"],["5TOA_A_ESTA601_1","ESTROGEN RECEPTOR BETA","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"ALA A 524;LEU A 531;ARG A 252;LEU A 188;LEU A 175","None","1.04A","5toaA-4ptfA:undetectable","5toaA-4ptfA:11.82"],["5TT3_H_EZLH303_1","ALPHA-CARBONIC ANHYDRASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"VAL A 426;LEU A 484;THR A 481;ALA A 480","None","0.82A","5tt3H-4ptfA:undetectable","5tt3H-4ptfA:11.81"],["5VCV_A_1N1A404_2","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"VAL A 971;LEU A 872;CYH A 881;ASP A 947","None","1.11A","5vcvA-4ptfA:undetectable","5vcvA-4ptfA:13.92"],["6ECF_I_DVAI3010_0","VLM2;DODECADEPSIPEPTIDE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",3,"PHE A 140;ARG A 252;ALA A 524","None","0.98A","6ecfB-4ptfA:undetectable","6ecfB-4ptfA:13.28"],["6GQI_A_ACTA604_0","CYCLOHEXANONE MONOOXYGENASE FROM THERMOCRISPUM MUNICIPALE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",4,"PRO A 532;TRP A 841;ILE A 529;GLU A 173","None","1.10A","6gqiA-4ptfA:undetectable","6gqiA-4ptfA:18.14"],["6R2E_F_FFOF403_0","THYMIDYLATE SYNTHASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"ILE A 857;ASN A 911;ASP A 640;GLY A 878;ALA A 642","None;None; CA A1203 (-2.6A); CA A1203 ( 4.4A);DCP A1201 ( 4.3A)","1.27A","6r2eF-4ptfA:undetectable","6r2eF-4ptfA:13.08"],["6R2E_H_FFOH403_0","THYMIDYLATE SYNTHASE","4ptf","DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A","Saccharomyces cerevisiae",5,"ILE A 857;ASN A 911;ASP A 640;GLY A 878;ALA A 642","None;None; CA A1203 (-2.6A); CA A1203 ( 4.4A);DCP A1201 ( 4.3A)","1.26A","6r2eH-4ptfA:undetectable","6r2eH-4ptfA:13.08"]]