SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 6 PHE A 235
ARG A 240
GLY A 276
THR A 278
 None
 1.15A 2f7fA-4ptsA:
undetectable		 2f7fA-4ptsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 5 TRP A  89
ALA A  59
LEU A 107
ALA A  53
 None
 1.29A 2jstA-4ptsA:
undetectable
2jstB-4ptsA:
undetectable		 2jstA-4ptsA:
13.28
2jstB-4ptsA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 8 ALA A 336
ARG A  49
PRO A 100
PRO A  95
 None
 0.95A 3fxrA-4ptsA:
undetectable		 3fxrA-4ptsA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		5 / 12 GLY A 274
THR A 278
ILE A 227
ARG A  66
LEU A  68
 None
 1.33A 3iv6C-4ptsA:
undetectable		 3iv6C-4ptsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		5 / 10 LEU A 212
LEU A 262
LEU A 256
ILE A 178
VAL A 186
 None
 1.35A 4mk4A-4ptsA:
undetectable		 4mk4A-4ptsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 7 ALA A 126
ALA A 110
GLU A 112
SER A  88
 None
 0.77A 4r1zB-4ptsA:
undetectable		 4r1zB-4ptsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		3 / 3 LEU A  68
ARG A 156
ARG A  67
 None
 0.88A 4yiaB-4ptsA:
undetectable		 4yiaB-4ptsA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 6 ARG A 233
ASP A 172
ARG A 168
ILE A 171
 None
 1.36A 5a06A-4ptsA:
undetectable		 5a06A-4ptsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 7 ARG A  61
THR A 236
TYR A 245
TYR A 179
 None
 1.13A 5hwaA-4ptsA:
undetectable		 5hwaA-4ptsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		5 / 12 TRP A 310
LEU A 256
MET A 259
THR A 279
LEU A 234
 None
 1.39A 5ienA-4ptsA:
undetectable		 5ienA-4ptsA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		3 / 3 GLU A 129
ARG A  47
TYR A  48
 None
 0.52A 5trqB-4ptsA:
undetectable		 5trqB-4ptsA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 5 LEU A 269
THR A 226
ARG A  67
PRO A 330
 None
 1.12A 6ew0B-4ptsA:
undetectable		 6ew0B-4ptsA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 5 LEU A 269
THR A 226
ARG A  67
PRO A 330
 None
 1.11A 6ew0D-4ptsA:
undetectable		 6ew0D-4ptsA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 5 LEU A 269
THR A 226
ARG A  67
PRO A 330
 None
 1.11A 6ew0H-4ptsA:
undetectable		 6ew0H-4ptsA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4pts GLUTATHIONE
S-TRANSFERASE
(Gordonia
bronchialis) 		4 / 5 LEU A 269
THR A 226
ARG A  67
PRO A 330
 None
 1.12A 6ew0I-4ptsA:
undetectable		 6ew0I-4ptsA:
13.44