SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ptx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 ALA A 190
VAL A 170
TRP A 134
 None
 0.91A 1gmkA-4ptxA:
undetectable
1gmkB-4ptxA:
undetectable		 1gmkA-4ptxA:
2.50
1gmkB-4ptxA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 ALA A 190
VAL A 170
TRP A 134
 None
 0.96A 1gmkC-4ptxA:
undetectable
1gmkD-4ptxA:
undetectable		 1gmkC-4ptxA:
2.50
1gmkD-4ptxA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 TRP A 249
VAL A 170
TRP A 168
 None
 1.38A 1gmkC-4ptxA:
undetectable
1gmkD-4ptxA:
undetectable		 1gmkC-4ptxA:
2.50
1gmkD-4ptxA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 4 LYS A 415
ALA A 358
MET A 325
 None
 1.07A 1hk3A-4ptxA:
undetectable		 1hk3A-4ptxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		5 / 12 SER A  17
ILE A  21
LEU A  67
GLY A 418
VAL A 422
 BGC  A 501 ( 4.9A)
None
None
None
None
 1.12A 1tlsA-4ptxA:
undetectable		 1tlsA-4ptxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 7 TYR A 377
HIS A 381
LEU A 334
TYR A 296
 None
None
None
BGC  A 501 (-4.1A)
 1.14A 1tuvA-4ptxA:
undetectable		 1tuvA-4ptxA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 PHE A 382
VAL A 442
TRP A 438
 None
 0.64A 2cc8A-4ptxA:
undetectable		 2cc8A-4ptxA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 PHE A 382
VAL A 442
TRP A 438
 None
 0.63A 2ccbA-4ptxA:
undetectable		 2ccbA-4ptxA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 5 ALA A 357
ASP A 405
ASP A 423
ASP A 371
 None
 1.12A 2nyuB-4ptxA:
undetectable		 2nyuB-4ptxA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 4 SER A  79
TRP A 122
ASP A  49
ILE A  45
 None
 1.42A 2oxtD-4ptxA:
undetectable		 2oxtD-4ptxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		5 / 11 ASN A 165
GLU A 166
TYR A 296
GLU A 354
TRP A 401
 BGC  A 501 (-3.3A)
BGC  A 501 (-2.4A)
BGC  A 501 (-4.1A)
BGC  A 501 (-2.7A)
BGC  A 501 (-3.6A)
 0.85A 2v3dB-4ptxA:
16.1		 2v3dB-4ptxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 PHE A 382
VAL A 442
TRP A 438
 None
 0.62A 2vx9A-4ptxA:
undetectable		 2vx9A-4ptxA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 5 VAL A 301
VAL A 315
THR A 224
ARG A 302
 None
 1.21A 3bjwA-4ptxA:
undetectable		 3bjwA-4ptxA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 5 VAL A 301
VAL A 315
THR A 224
ARG A 302
 None
 1.22A 3bjwC-4ptxA:
undetectable		 3bjwC-4ptxA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 8 TYR A 120
ASN A 165
PHE A 417
TRP A 401
 None
BGC  A 501 (-3.3A)
BGC  A 501 (-3.8A)
BGC  A 501 (-3.6A)
 1.43A 3bjwD-4ptxA:
undetectable		 3bjwD-4ptxA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		5 / 12 LEU A 271
LEU A 191
ILE A 266
LEU A 263
PHE A 310
 None
 1.13A 3fl9B-4ptxA:
undetectable		 3fl9B-4ptxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		5 / 12 ASP A 282
ILE A 283
GLY A 279
TYR A 259
HIS A 195
 CAC  A 502 (-3.8A)
None
None
None
None
 1.31A 3hgiA-4ptxA:
undetectable		 3hgiA-4ptxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 8 TYR A 439
TYR A 399
PHE A 382
ILE A   4
 None
 1.06A 3jz0B-4ptxA:
undetectable		 3jz0B-4ptxA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 TYR A  58
ASP A  56
ASP A  52
 None
 0.89A 3ou7B-4ptxA:
undetectable		 3ou7B-4ptxA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 6 GLY A  91
LEU A 128
TYR A 142
GLU A 145
 None
 0.90A 3w9tB-4ptxA:
undetectable		 3w9tB-4ptxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 6 GLY A  91
LEU A 128
TYR A 142
GLU A 145
 None
 0.90A 3w9tE-4ptxA:
undetectable		 3w9tE-4ptxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 6 GLY A  91
LEU A 128
TYR A 142
GLU A 145
 None
 0.92A 3w9tF-4ptxA:
undetectable		 3w9tF-4ptxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 7 PRO A 182
ILE A  34
GLN A 129
GLY A 133
 None
 0.97A 4a3uB-4ptxA:
14.2		 4a3uB-4ptxA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 7 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.78A 4c5nA-4ptxA:
2.5		 4c5nA-4ptxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 8 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.72A 4c5nC-4ptxA:
2.9		 4c5nC-4ptxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 ASP A 123
TRP A 401
SER A  79
 None
BGC  A 501 (-3.6A)
None
 0.98A 4lrhB-4ptxA:
undetectable		 4lrhB-4ptxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 ASP A 123
TRP A 401
SER A  79
 None
BGC  A 501 (-3.6A)
None
 1.07A 4lrhF-4ptxA:
undetectable		 4lrhF-4ptxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 SER A 297
TYR A 296
TYR A 295
 None
BGC  A 501 (-4.1A)
None
 0.78A 5lakA-4ptxA:
undetectable
5lakI-4ptxA:
undetectable		 5lakA-4ptxA:
22.48
5lakI-4ptxA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 SER A 297
TYR A 296
TYR A 295
 None
BGC  A 501 (-4.1A)
None
 0.68A 5lakC-4ptxA:
undetectable
5lakJ-4ptxA:
undetectable		 5lakC-4ptxA:
22.48
5lakJ-4ptxA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 5 HIS A 121
HIS A 201
LEU A 251
VAL A 254
 BGC  A 501 (-4.2A)
None
None
None
 1.04A 6bc9A-4ptxA:
undetectable		 6bc9A-4ptxA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		4 / 4 ILE A 293
LEU A 395
HIS A 381
ALA A 385
 None
 0.88A 6ck2C-4ptxA:
undetectable
6ck2D-4ptxA:
undetectable		 6ck2C-4ptxA:
3.68
6ck2D-4ptxA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 TYR A  61
HIS A  57
PHE A 100
 None
 0.96A 6esmA-4ptxA:
undetectable		 6esmA-4ptxA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4ptx GLYCOSIDE HYDROLASE
FAMILY 1
(Halothermothrix
orenii) 		3 / 3 TYR A 259
HIS A 264
PHE A 274
 None
 1.02A 6esmA-4ptxA:
undetectable		 6esmA-4ptxA:
11.69