SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ptz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 6 LEU C 104
ALA C  22
LEU C  18
SER C  17
 None
 1.01A 1tz8C-4ptzC:
undetectable
1tz8D-4ptzC:
undetectable		 1tz8C-4ptzC:
20.30
1tz8D-4ptzC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 4 LEU C  18
SER C  17
TYR C  21
LEU C 160
 None
 1.17A 1xz1A-4ptzC:
undetectable		 1xz1A-4ptzC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 4 LEU C  18
SER C  17
TYR C  21
LEU C 160
 None
 1.18A 1xz3A-4ptzC:
undetectable		 1xz3A-4ptzC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 11 SER C   8
SER C  13
ALA C   6
ALA C  72
ARG C  23
 FMN  C 201 (-2.6A)
FMN  C 201 (-2.5A)
None
None
None
 1.23A 2xh9A-4ptzC:
undetectable		 2xh9A-4ptzC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 11 SER C   8
SER C  13
ALA C   6
GLY C   7
ALA C  72
 FMN  C 201 (-2.6A)
FMN  C 201 (-2.5A)
None
None
None
 1.43A 2xh9A-4ptzC:
undetectable		 2xh9A-4ptzC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 10 SER C   8
SER C  13
ALA C   6
ALA C  72
ARG C  23
 FMN  C 201 (-2.6A)
FMN  C 201 (-2.5A)
None
None
None
 1.19A 2xh9B-4ptzC:
undetectable		 2xh9B-4ptzC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 10 SER C   8
SER C  13
ALA C   6
GLY C   7
ALA C  72
 FMN  C 201 (-2.6A)
FMN  C 201 (-2.5A)
None
None
None
 1.39A 2xh9B-4ptzC:
undetectable		 2xh9B-4ptzC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 5 LEU C 133
GLN C 169
THR C 166
GLU C 131
 None
 1.48A 3n58C-4ptzC:
5.1		 3n58C-4ptzC:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 9 PRO C  74
SER C  15
LEU C  84
SER C  13
LEU C  38
 FMN  C 201 (-4.1A)
FMN  C 201 (-2.5A)
None
FMN  C 201 (-2.5A)
None
 1.32A 3w1wA-4ptzC:
3.5
3w1wB-4ptzC:
3.0		 3w1wA-4ptzC:
21.36
3w1wB-4ptzC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 9 SER C  13
LEU C  38
PRO C  74
SER C  15
LEU C  84
 FMN  C 201 (-2.5A)
None
FMN  C 201 (-4.1A)
FMN  C 201 (-2.5A)
None
 1.23A 3w1wA-4ptzC:
3.5
3w1wB-4ptzC:
3.0		 3w1wA-4ptzC:
21.36
3w1wB-4ptzC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 10 THR C 166
LEU C 104
LEU C 102
GLY C 135
ASP C 161
 None
 1.29A 4c9nB-4ptzC:
undetectable		 4c9nB-4ptzC:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 6 LEU C 104
ALA C  22
LEU C  18
SER C  17
 None
 1.03A 4i89A-4ptzC:
undetectable		 4i89A-4ptzC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		3 / 3 TYR C 146
ARG C  10
SER C  13
 None
FMN  C 202 ( 3.0A)
FMN  C 201 (-2.5A)
 0.98A 4lf7I-4ptzC:
undetectable
4lf7J-4ptzC:
undetectable		 4lf7I-4ptzC:
24.62
4lf7J-4ptzC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		3 / 3 TYR C 146
ARG C  10
SER C  13
 None
FMN  C 202 ( 3.0A)
FMN  C 201 (-2.5A)
 0.98A 4lf8I-4ptzC:
undetectable
4lf8J-4ptzC:
undetectable		 4lf8I-4ptzC:
24.62
4lf8J-4ptzC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		3 / 3 LEU C 114
ASP C 117
TYR C 118
 None
 0.50A 4qc6B-4ptzC:
undetectable		 4qc6B-4ptzC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 9 VAL C  31
VAL C  33
ILE C  70
PHE C 167
LEU C 171
 None
 1.36A 5e4dA-4ptzC:
undetectable		 5e4dA-4ptzC:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 6 LEU C 104
ALA C  22
LEU C  18
SER C  17
 None
 1.01A 5l4iA-4ptzC:
undetectable		 5l4iA-4ptzC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		5 / 12 VAL C 143
ALA C 163
LEU C 104
ALA C  72
LEU C 102
 None
 1.01A 6bq4A-4ptzC:
undetectable		 6bq4A-4ptzC:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 5 LEU C  63
LEU C  87
THR C   4
PRO C  74
 None
None
None
FMN  C 201 (-4.1A)
 1.01A 6ew0F-4ptzC:
undetectable		 6ew0F-4ptzC:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4ptz FMN REDUCTASE SSUE
(Escherichia
coli) 		4 / 6 LEU C  63
LEU C  87
THR C   4
PRO C  74
 None
None
None
FMN  C 201 (-4.1A)
 1.01A 6ew0G-4ptzC:
undetectable		 6ew0G-4ptzC:
17.99