SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 7 LEU A 199
VAL A 198
LEU A 415
LEU A 414
 None
 0.80A 1cqpA-4pu5A:
undetectable
1cqpB-4pu5A:
undetectable		 1cqpA-4pu5A:
17.22
1cqpB-4pu5A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 7 SER A 313
CYH A 242
ASN A 311
TYR A 312
 ANP  A 503 ( 4.2A)
None
MG  A 502 ( 2.5A)
None
 0.98A 1dssG-4pu5A:
undetectable		 1dssG-4pu5A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 8 SER A 313
CYH A 242
ASN A 311
TYR A 312
 ANP  A 503 ( 4.2A)
None
MG  A 502 ( 2.5A)
None
 0.98A 1dssR-4pu5A:
undetectable		 1dssR-4pu5A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		3 / 3 GLN A  40
ILE A 103
HIS A 237
 None
 0.71A 1fm9A-4pu5A:
undetectable		 1fm9A-4pu5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 THR A 192
ARG A 417
LEU A 414
TYR A 410
GLY A 303
 None
 1.30A 1httB-4pu5A:
undetectable		 1httB-4pu5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 THR A 192
ARG A 417
LEU A 414
TYR A 410
GLY A 303
 None
 1.27A 1httC-4pu5A:
undetectable		 1httC-4pu5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		3 / 3 GLN A  40
ILE A 103
HIS A 237
 None
 0.75A 1k74A-4pu5A:
undetectable		 1k74A-4pu5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		3 / 3 ASP A 240
HIS A 308
ASP A 328
 None
ANP  A 503 (-3.7A)
MG  A 501 (-1.9A)
 0.73A 1nw5A-4pu5A:
undetectable		 1nw5A-4pu5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 8 LYS A 215
ILE A 208
GLU A 403
ILE A 187
 None
 0.91A 2j9dJ-4pu5A:
undetectable
2j9dK-4pu5A:
0.5
2j9dL-4pu5A:
undetectable		 2j9dJ-4pu5A:
15.19
2j9dK-4pu5A:
15.19
2j9dL-4pu5A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 6 GLN A 294
ASN A 377
ASN A 311
LEU A 329
 None
None
MG  A 502 ( 2.5A)
None
 1.15A 2nyrA-4pu5A:
undetectable		 2nyrA-4pu5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 6 ASP A 430
TYR A 358
PHE A 424
LEU A 360
 None
 1.18A 2w98A-4pu5A:
undetectable
2w98B-4pu5A:
undetectable		 2w98A-4pu5A:
21.95
2w98B-4pu5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 8 SER A 313
CYH A 242
ASN A 311
TYR A 312
 ANP  A 503 ( 4.2A)
None
MG  A 502 ( 2.5A)
None
 1.00A 3dmtC-4pu5A:
undetectable		 3dmtC-4pu5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 8 PHE A 179
GLY A  73
PHE A 164
PHE A 211
 None
 1.06A 3ko0B-4pu5A:
undetectable
3ko0J-4pu5A:
undetectable		 3ko0B-4pu5A:
12.61
3ko0J-4pu5A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 7 PHE A 105
ILE A  60
VAL A  32
TYR A  34
 None
 1.00A 3p6hA-4pu5A:
undetectable		 3p6hA-4pu5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 10 LEU A  67
ALA A 104
PHE A 105
GLY A  96
ILE A  95
 None
 1.19A 3qpsA-4pu5A:
undetectable		 3qpsA-4pu5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 ILE A 120
PHE A 166
TRP A 140
ALA A 122
VAL A 177
 None
 1.18A 3s79A-4pu5A:
undetectable		 3s79A-4pu5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 8 PRO A 397
ILE A 208
ILE A 191
ARG A 194
 None
 1.11A 3sfeB-4pu5A:
undetectable
3sfeC-4pu5A:
undetectable		 3sfeB-4pu5A:
18.53
3sfeC-4pu5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 7 ILE A  95
ASP A  75
LEU A  74
GLY A  73
 None
 0.85A 4iqqB-4pu5A:
undetectable		 4iqqB-4pu5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 MET A 201
ILE A 381
LEU A 374
ALA A 296
LEU A 301
 None
 0.97A 4m11B-4pu5A:
undetectable		 4m11B-4pu5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 ASN A 284
GLU A 322
ASN A 202
TYR A 312
PHE A 314
 None
 1.49A 5ccmA-4pu5A:
undetectable		 5ccmA-4pu5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		3 / 3 THR A   3
THR A   6
PHE A  23
 None
 0.90A 5cxvA-4pu5A:
undetectable		 5cxvA-4pu5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		3 / 3 ALA A 296
ASN A 299
LEU A 300
 None
 0.40A 5i1oC-4pu5A:
undetectable		 5i1oC-4pu5A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		3 / 3 ALA A 296
ASN A 299
LEU A 300
 None
 0.37A 5i1pA-4pu5A:
undetectable		 5i1pA-4pu5A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 ILE A 120
PHE A 166
TRP A 140
ALA A 122
VAL A 177
 None
 1.20A 5jkvA-4pu5A:
undetectable		 5jkvA-4pu5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 GLY A  19
HIS A  33
GLU A  20
ASP A  52
ILE A  49
 None
 1.04A 5njvD-4pu5A:
undetectable		 5njvD-4pu5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 7 ILE A  95
ASP A  75
LEU A  74
GLY A  73
 None
 0.88A 5nooB-4pu5A:
undetectable		 5nooB-4pu5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		4 / 5 ILE A  95
SER A 147
ALA A 104
LEU A   9
 None
 1.02A 6dwnA-4pu5A:
undetectable		 6dwnA-4pu5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0B-4pu5A:
undetectable		 6ew0B-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0D-4pu5A:
undetectable		 6ew0D-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.13A 6ew0F-4pu5A:
undetectable		 6ew0F-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0G-4pu5A:
undetectable		 6ew0G-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0H-4pu5A:
undetectable		 6ew0H-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY
(Shewanella
oneidensis) 		5 / 12 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0I-4pu5A:
undetectable		 6ew0I-4pu5A:
11.73