SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 6 GLY A  93
ALA A  82
TYR A 119
GLU A  81
 None
 1.03A 1dmaB-4pu6A:
undetectable		 1dmaB-4pu6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris;
Phaseolus
vulgaris) 		5 / 10 ILE B 292
GLY B 290
THR B 246
HIS A   9
GLY B 308
 None
None
ASP  B 501 (-3.6A)
None
None
 1.19A 1i7qC-4pu6B:
undetectable		 1i7qC-4pu6B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 6 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.05A 1iepA-4pu6B:
undetectable		 1iepA-4pu6B:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		5 / 11 PHE B 310
LEU A  58
HIS A   9
ALA A  12
GLY B 308
 None
 1.33A 1l5rA-4pu6B:
undetectable		 1l5rA-4pu6B:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 6 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.00A 1opjB-4pu6B:
undetectable		 1opjB-4pu6B:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
(Phaseolus
vulgaris) 		3 / 3 ASP A 146
GLU A  21
ARG A  32
 None
 0.85A 1wopA-4pu6A:
undetectable		 1wopA-4pu6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 4 GLY A  37
VAL A  50
GLY B 198
THR B 212
 None
 0.84A 3ib2A-4pu6A:
undetectable		 3ib2A-4pu6A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 7 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.04A 3ik3A-4pu6B:
undetectable		 3ik3A-4pu6B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		5 / 11 THR B 246
THR B 212
ALA A  82
GLY A  10
SER B 244
 ASP  B 501 (-3.6A)
None
None
None
None
 1.14A 3mg0N-4pu6B:
5.3		 3mg0N-4pu6B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 7 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.06A 3mssB-4pu6B:
undetectable		 3mssB-4pu6B:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
(Phaseolus
vulgaris) 		5 / 10 GLY A  93
ALA A 108
ILE A  48
VAL A  55
ILE A 105
 None
 0.94A 3nu6B-4pu6A:
undetectable		 3nu6B-4pu6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 5 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.11A 3oezA-4pu6B:
undetectable		 3oezA-4pu6B:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
(Phaseolus
vulgaris) 		5 / 12 GLY A  93
ALA A 108
ILE A  48
VAL A  55
ILE A 105
 None
 0.96A 3pwmB-4pu6A:
undetectable		 3pwmB-4pu6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 5 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.15A 3pyyB-4pu6B:
undetectable		 3pyyB-4pu6B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pu6 L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 6 LEU B 270
GLU B 260
VAL B 243
ALA B 293
 None
 0.99A 4nkvC-4pu6B:
undetectable		 4nkvC-4pu6B:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pu6 L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris) 		4 / 6 LEU B 270
GLU B 260
VAL B 243
ALA B 293
 None
 0.95A 4nkxA-4pu6B:
undetectable		 4nkxA-4pu6B:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT
(Phaseolus
vulgaris;
Phaseolus
vulgaris) 		4 / 5 ILE B 292
CYH B 199
LEU A  58
HIS A   9
 None
 1.13A 5hrqC-4pu6B:
undetectable
5hrqD-4pu6B:
undetectable
5hrqL-4pu6B:
undetectable		 5hrqC-4pu6B:
9.09
5hrqD-4pu6B:
15.00
5hrqL-4pu6B:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
(Phaseolus
vulgaris) 		5 / 10 VAL A 101
GLY A  97
LEU A 110
ILE A 120
ALA A 129
 None
 1.07A 5vm8B-4pu6A:
undetectable		 5vm8B-4pu6A:
24.22