SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 220
TYR A 223
LEU A 230
ALA A 227
 None
 0.86A 1dmaA-4puaA:
undetectable		 1dmaA-4puaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 LEU A 222
ILE A 245
ARG A 248
TYR A 214
 None
 1.37A 1rk3A-4puaA:
undetectable		 1rk3A-4puaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 ALA A 101
LEU A 102
ILE A 119
SER A  47
 None
 0.89A 1sbrA-4puaA:
undetectable
1sbrB-4puaA:
undetectable		 1sbrA-4puaA:
22.76
1sbrB-4puaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 222
ILE A 245
ARG A 248
TYR A 214
 None
 1.37A 2zlcA-4puaA:
undetectable		 2zlcA-4puaA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 222
TYR A 223
PHE A 159
LEU A 155
 None
 0.83A 3i45A-4puaA:
undetectable		 3i45A-4puaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 207
TYR A 203
TRP A 241
 None
 1.42A 4p7nA-4puaA:
undetectable		 4p7nA-4puaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.77A 4zdzA-4puaA:
undetectable		 4zdzA-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.79A 4ze3A-4puaA:
undetectable		 4ze3A-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A  36
PRO A 100
LEU A  93
GLY A  39
GLN A  44
 None
GSH  A 302 ( 4.7A)
None
None
None
 1.43A 4zp0A-4puaA:
0.4		 4zp0A-4puaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.80A 5esjA-4puaA:
undetectable		 5esjA-4puaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.75A 5esmA-4puaA:
undetectable		 5esmA-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  80
GLY A  53
THR A  57
LEU A  45
 GSH  A 302 ( 3.8A)
None
None
None
 0.87A 5hs1A-4puaA:
undetectable		 5hs1A-4puaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.64A 5hs1A-4puaA:
undetectable		 5hs1A-4puaA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A  48
ILE A  80
TYR A 165
 None
GSH  A 302 ( 3.8A)
None
 0.35A 5uunB-4puaA:
36.0		 5uunB-4puaA:
49.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A  20
PRO A  51
TYR A 165
TYR A 223
 GSH  A 301 (-3.4A)
None
None
None
 0.67A 5uunB-4puaA:
36.0		 5uunB-4puaA:
49.65