SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4puc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 TRP A 313
ALA A 290
VAL A 319
 None
 0.94A 1c4dC-4pucA:
undetectable
1c4dD-4pucA:
undetectable		 1c4dC-4pucA:
3.73
1c4dD-4pucA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 7 SER A 397
SER A 306
ALA A 392
PHE A 387
 None
 1.21A 1fxvA-4pucA:
undetectable
1fxvB-4pucA:
undetectable		 1fxvA-4pucA:
19.10
1fxvB-4pucA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 ARG A 147
GLY A  73
ASP A  69
 None
 0.51A 1kf6A-4pucA:
2.3
1kf6B-4pucA:
0.5		 1kf6A-4pucA:
21.34
1kf6B-4pucA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 12 LEU A 118
ILE A 140
SER A 187
TYR A 134
LEU A 199
 None
 1.14A 1s19A-4pucA:
undetectable		 1s19A-4pucA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 ALA A 290
VAL A 319
TRP A 313
 None
 0.86A 1tkqB-4pucA:
undetectable		 1tkqB-4pucA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 12 GLY A  78
GLY A  73
GLY A 454
ALA A 457
PHE A  67
 None
 1.10A 2dpmA-4pucA:
undetectable		 2dpmA-4pucA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 ASN A 117
TYR A  44
SER A  51
 None
 0.75A 2gvcB-4pucA:
undetectable		 2gvcB-4pucA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 ASN A 117
TYR A  44
SER A  51
 None
 0.73A 2gvcE-4pucA:
undetectable		 2gvcE-4pucA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 ARG A 462
GLY A 153
PRO A 154
 None
 0.64A 2hreD-4pucA:
undetectable		 2hreD-4pucA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 8 HIS A 247
ALA A 218
LEU A 191
THR A 192
 None
 0.90A 2it4A-4pucA:
undetectable		 2it4A-4pucA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 5 GLN A 173
THR A 149
ALA A 151
ARG A 462
 None
 1.25A 2qhfA-4pucA:
undetectable		 2qhfA-4pucA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 5 LEU A 415
ARG A 322
ALA A 413
ILE A 325
 None
 1.07A 2qhfA-4pucA:
undetectable		 2qhfA-4pucA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 7 ASP A 171
SER A 158
GLU A 186
ASP A 185
 None
 1.30A 3bc9A-4pucA:
undetectable		 3bc9A-4pucA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 4 TYR A 337
LEU A 321
ARG A 323
TYR A 409
 None
 1.33A 3gf2A-4pucA:
0.0		 3gf2A-4pucA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 7 TYR A 295
TYR A 299
TYR A 398
PHE A 387
 None
 1.21A 3ku9B-4pucA:
undetectable		 3ku9B-4pucA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 12 GLU A 380
GLY A 382
PHE A 387
ALA A 449
GLN A 445
 ACT  A 604 (-3.7A)
None
None
None
None
 1.07A 3nvkF-4pucA:
undetectable
3nvkJ-4pucA:
undetectable		 3nvkF-4pucA:
23.26
3nvkJ-4pucA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 10 ALA A 137
LEU A 114
ASN A 117
LEU A 118
VAL A 121
 None
 0.71A 3o02A-4pucA:
1.2
3o02B-4pucA:
1.0		 3o02A-4pucA:
21.49
3o02B-4pucA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 9 GLY A  78
TRP A 458
ALA A 459
ASP A 460
ARG A 462
 None
 1.28A 3ur0C-4pucA:
0.5		 3ur0C-4pucA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 8 TRP A 313
ARG A 322
THR A 417
TYR A 333
 None
 1.49A 3wipA-4pucA:
undetectable
3wipE-4pucA:
undetectable		 3wipA-4pucA:
18.62
3wipE-4pucA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 12 ALA A  65
GLN A  66
GLY A  73
CYH A  70
ALA A 457
 None
 1.08A 4pclA-4pucA:
undetectable		 4pclA-4pucA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 PRO A 270
LEU A 271
GLN A  66
 None
 0.70A 4pevB-4pucA:
undetectable		 4pevB-4pucA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 7 PHE A  67
SER A 107
ILE A  58
ASP A  61
 None
 0.86A 5n5dA-4pucA:
undetectable		 5n5dA-4pucA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 7 ILE A 140
TRP A 261
TRP A 350
SER A  60
 None
 1.43A 5nr3A-4pucA:
undetectable		 5nr3A-4pucA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		4 / 5 THR A 364
GLU A 242
HIS A 247
LEU A 251
 None
 0.96A 5utuH-4pucA:
undetectable		 5utuH-4pucA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		5 / 12 GLY A  73
GLY A 454
ALA A 457
ILE A  91
LEU A  72
 None
 1.18A 6b3bA-4pucA:
undetectable		 6b3bA-4pucA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4puc SUSD HOMOLOG
(Bacteroides
uniformis) 		3 / 3 ARG A 304
ARG A 303
ASP A 301
 None
 0.97A 6d8pA-4pucA:
undetectable		 6d8pA-4pucA:
20.88