SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		3 / 3 PHE A 217
TYR A 227
PRO A 225
 None
1PE  A 503 (-4.1A)
None
 1.06A 1mcnA-4pv4A:
undetectable
1mcnB-4pv4A:
undetectable
1mcnP-4pv4A:
undetectable		 1mcnA-4pv4A:
18.96
1mcnB-4pv4A:
18.96
1mcnP-4pv4A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
ALA A 420
GLY A 260
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.24A 1nbiC-4pv4A:
undetectable		 1nbiC-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
GLY A 260
SER A 189
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.29A 1nbiC-4pv4A:
undetectable		 1nbiC-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
ALA A 420
GLY A 260
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.25A 1nbiD-4pv4A:
undetectable		 1nbiD-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
GLY A 260
SER A 189
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.27A 1nbiD-4pv4A:
undetectable		 1nbiD-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.82A 1rl8A-4pv4A:
undetectable		 1rl8A-4pv4A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 6 LEU A 143
PHE A 140
ALA A 141
LEU A 119
 EDO  A 505 ( 4.6A)
None
PGE  A 504 (-3.6A)
None
 0.81A 1ukbA-4pv4A:
undetectable		 1ukbA-4pv4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 5 ILE A 408
SER A 189
LEU A 418
ASN A 417
 None
 1.16A 1y0xX-4pv4A:
undetectable		 1y0xX-4pv4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 4 LEU A 373
LEU A 301
SER A 298
LEU A 350
 None
 1.13A 1ya3A-4pv4A:
undetectable		 1ya3A-4pv4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 PHE A  75
ASN A  76
GLY A  92
THR A  98
 None
 1.08A 1ykiA-4pv4A:
undetectable
1ykiB-4pv4A:
undetectable		 1ykiA-4pv4A:
20.18
1ykiB-4pv4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 THR A  98
PHE A  75
ASN A  76
GLY A  92
 None
 1.05A 1ykiA-4pv4A:
undetectable
1ykiB-4pv4A:
undetectable		 1ykiA-4pv4A:
20.18
1ykiB-4pv4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 PHE A  75
ASN A  76
GLY A  92
THR A  98
 None
 1.07A 1ykiC-4pv4A:
undetectable
1ykiD-4pv4A:
undetectable		 1ykiC-4pv4A:
20.18
1ykiD-4pv4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 TYR A 386
PHE A 345
GLY A 384
THR A 312
 None
 1.08A 1ykiC-4pv4A:
undetectable
1ykiD-4pv4A:
undetectable		 1ykiC-4pv4A:
20.18
1ykiD-4pv4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 5 PRO A 389
GLY A 237
ASN A 236
GLY A 234
 None
 1.06A 1zlqA-4pv4A:
undetectable		 1zlqA-4pv4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 10 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.90A 2aquA-4pv4A:
undetectable		 2aquA-4pv4A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.87A 2fxeB-4pv4A:
undetectable		 2fxeB-4pv4A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.80A 2nmyA-4pv4A:
undetectable		 2nmyA-4pv4A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 THR A 419
VAL A 422
GLU A 405
ARG A 272
 None
None
MG  A 501 ( 2.5A)
None
 1.12A 2v41G-4pv4A:
undetectable
2v41H-4pv4A:
undetectable		 2v41G-4pv4A:
18.88
2v41H-4pv4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 ILE A 295
LEU A 379
LEU A 299
ILE A 408
THR A 419
 None
 1.26A 3a50B-4pv4A:
undetectable		 3a50B-4pv4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 ILE A 295
LEU A 379
LEU A 299
ILE A 408
THR A 419
 None
 1.24A 3a50C-4pv4A:
undetectable		 3a50C-4pv4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ILE A 295
LEU A 379
LEU A 299
ILE A 408
THR A 419
 None
 1.21A 3a50E-4pv4A:
undetectable		 3a50E-4pv4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.84A 3ekwB-4pv4A:
undetectable		 3ekwB-4pv4A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
MG  A 501 ( 2.0A)
None
 0.64A 3el0A-4pv4A:
undetectable		 3el0A-4pv4A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.81A 3em4U-4pv4A:
undetectable		 3em4U-4pv4A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 9 MET A 319
LEU A 385
ARG A 343
SER A 298
GLY A 349
 None
 1.38A 3hcnB-4pv4A:
undetectable		 3hcnB-4pv4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 9 MET A 319
LEU A 385
ARG A 343
SER A 298
GLY A 349
 None
 1.41A 3hcoA-4pv4A:
undetectable		 3hcoA-4pv4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 10 MET A 319
LEU A 385
ARG A 343
SER A 298
GLY A 349
 None
 1.38A 3hcoB-4pv4A:
2.1		 3hcoB-4pv4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 GLY A 355
ARG A 171
ASP A 407
GLY A 260
ARG A  42
 None
 1.25A 3k13B-4pv4A:
undetectable		 3k13B-4pv4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 GLY A 355
ARG A 171
ASP A 407
GLY A 260
ARG A  42
 None
 1.26A 3k13C-4pv4A:
undetectable		 3k13C-4pv4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.80A 3ndwA-4pv4A:
undetectable		 3ndwA-4pv4A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.80A 3ndxA-4pv4A:
undetectable		 3ndxA-4pv4A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.85A 3ndxB-4pv4A:
undetectable		 3ndxB-4pv4A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.73A 3oxxC-4pv4A:
undetectable		 3oxxC-4pv4A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		6 / 12 ILE A 213
LEU A 249
ILE A 400
THR A 273
TYR A 288
ILE A 402
 None
 1.35A 3pwwA-4pv4A:
undetectable		 3pwwA-4pv4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 LEU A 299
ALA A 420
THR A 419
LEU A 418
LEU A 354
 None
 1.15A 3r9cA-4pv4A:
undetectable		 3r9cA-4pv4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 5 ASN A  44
ALA A  28
TYR A 134
ALA A 135
 None
 1.34A 3twpD-4pv4A:
undetectable		 3twpD-4pv4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 9 PRO A 275
GLN A 284
LEU A 292
ILE A 429
MET A 433
 None
 1.30A 4c66A-4pv4A:
undetectable		 4c66A-4pv4A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 4 ALA A 135
VAL A 139
ASP A 136
LEU A 160
 None
None
None
EDO  A 505 (-4.9A)
 1.20A 4e7gA-4pv4A:
undetectable		 4e7gA-4pv4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ARG A 219
GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
None
MG  A 501 ( 2.0A)
None
 0.87A 4njvA-4pv4A:
undetectable		 4njvA-4pv4A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		3 / 3 ASP A 269
ASP A 258
ASN A 228
 MG  A 501 ( 2.5A)
MG  A 501 ( 2.0A)
None
 0.80A 4q5mA-4pv4A:
undetectable		 4q5mA-4pv4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 LEU A 432
ILE A 402
ILE A 257
VAL A 423
ILE A 429
 None
 0.95A 4qgiB-4pv4A:
undetectable		 4qgiB-4pv4A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 11 ILE A 270
GLY A 260
ASP A 407
GLU A 382
THR A 419
 None
None
None
MG  A 502 ( 2.6A)
None
 1.39A 4xt7A-4pv4A:
undetectable		 4xt7A-4pv4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 SER A  21
ALA A  22
LEU A  14
LEU A  13
 None
 1.02A 5dzkF-4pv4A:
undetectable
5dzkT-4pv4A:
undetectable		 5dzkF-4pv4A:
18.49
5dzkT-4pv4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 9 LEU A 432
ILE A 402
ILE A 257
VAL A 423
ILE A 429
 None
 1.05A 5kr2D-4pv4A:
undetectable		 5kr2D-4pv4A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 5 ARG A 272
THR A 194
HIS A 193
ALA A 190
 None
 1.32A 5mfxA-4pv4A:
undetectable		 5mfxA-4pv4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 GLU A   5
LEU A  62
LEU A  50
LEU A 167
ALA A  12
 None
 1.21A 5v0vA-4pv4A:
undetectable		 5v0vA-4pv4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 ILE A 111
PHE A  26
ILE A  61
ALA A  22
ALA A 156
 None
None
None
None
EDO  A 505 ( 4.9A)
 0.99A 5vceA-4pv4A:
undetectable		 5vceA-4pv4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 GLY A 401
ILE A 270
ALA A 259
THR A 229
GLY A 237
 None
 1.00A 5veuH-4pv4A:
0.8		 5veuH-4pv4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 7 ARG A   9
TYR A 266
LEU A 354
VAL A 378
 None
 1.30A 6g2pA-4pv4A:
undetectable		 6g2pA-4pv4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 8 ASP A  80
ARG A  77
GLU A  55
GLU A  30
 None
 1.18A 6mn4A-4pv4A:
undetectable		 6mn4A-4pv4A:
21.85