SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 12 PRO A 177
ILE A 164
ALA A 131
SER A 137
GLU A 143
 None
 1.12A 1sg9C-4pv5A:
undetectable		 1sg9C-4pv5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		4 / 7 TYR A 136
SER A 137
CYH A 139
ILE A 174
 None
 1.03A 2xz5A-4pv5A:
undetectable
2xz5B-4pv5A:
undetectable		 2xz5A-4pv5A:
20.35
2xz5B-4pv5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		4 / 8 TYR A 136
SER A 137
CYH A 139
ILE A 174
 None
 1.02A 2xz5B-4pv5A:
undetectable
2xz5E-4pv5A:
undetectable		 2xz5B-4pv5A:
20.35
2xz5E-4pv5A:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 12 LYS A 151
GLY A 156
LYS A 157
LEU A 161
PHE A 163
 CBW  A 202 (-4.4A)
CBW  A 202 (-3.5A)
None
None
CBW  A 202 ( 4.6A)
 0.42A 4kykA-4pv5A:
25.8
4kykB-4pv5A:
25.4		 4kykA-4pv5A:
100.00
4kykB-4pv5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 12 LYS A 151
GLY A 156
LYS A 157
MET A 158
LEU A 161
 CBW  A 202 (-4.4A)
CBW  A 202 (-3.5A)
None
None
None
 0.81A 4kykA-4pv5A:
25.8
4kykB-4pv5A:
25.4		 4kykA-4pv5A:
100.00
4kykB-4pv5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 12 PHE A  63
ALA A  65
PHE A  68
LEU A  70
PHE A  93
 None
 0.23A 4kykA-4pv5A:
25.8
4kykB-4pv5A:
25.4		 4kykA-4pv5A:
100.00
4kykB-4pv5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		3 / 3 SER A  45
ASP A 168
GLN A 113
 None
 0.96A 4oltA-4pv5A:
undetectable
4oltB-4pv5A:
undetectable		 4oltA-4pv5A:
18.78
4oltB-4pv5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		4 / 8 ILE A  39
ASP A 168
PRO A 167
LEU A 101
 None
 0.87A 4qopC-4pv5A:
undetectable		 4qopC-4pv5A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 10 TYR A 115
TYR A 170
ILE A 172
ILE A 174
LEU A 175
 None
 1.17A 5vkqA-4pv5A:
undetectable
5vkqD-4pv5A:
undetectable		 5vkqA-4pv5A:
7.50
5vkqD-4pv5A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 10 TYR A 115
TYR A 170
ILE A 172
ILE A 174
LEU A 175
 None
 1.17A 5vkqA-4pv5A:
undetectable
5vkqB-4pv5A:
undetectable		 5vkqA-4pv5A:
7.50
5vkqB-4pv5A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 9 TYR A 115
TYR A 170
ILE A 172
ILE A 174
LEU A 175
 None
 1.17A 5vkqB-4pv5A:
undetectable
5vkqC-4pv5A:
undetectable		 5vkqB-4pv5A:
7.50
5vkqC-4pv5A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pv5 LACTOYLGLUTATHIONE
LYASE
(Mus
musculus) 		5 / 10 TYR A 115
TYR A 170
ILE A 172
ILE A 174
LEU A 175
 None
 1.18A 5vkqC-4pv5A:
undetectable
5vkqD-4pv5A:
undetectable		 5vkqC-4pv5A:
7.50
5vkqD-4pv5A:
7.50