SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 274
VAL A 220
ILE A 328
ILE A 240
THR A 215
 None
 0.98A 1c6zB-4pvcA:
undetectable		 1c6zB-4pvcA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 321
ALA A 248
TYR A 128
PHE A 236
ILE A 264
 None
 1.19A 1mx8A-4pvcA:
undetectable		 1mx8A-4pvcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  19
ARG A 243
ILE A  16
 None
 0.55A 2xn5B-4pvcA:
undetectable		 2xn5B-4pvcA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		4 / 8 THR A 331
LEU A 279
ASP A 274
GLU A 218
 None
 1.01A 2zw9A-4pvcA:
5.1		 2zw9A-4pvcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 277
ASN A 280
SER A 297
 None
 0.94A 3lslA-4pvcA:
undetectable
3lslD-4pvcA:
undetectable		 3lslA-4pvcA:
24.51
3lslD-4pvcA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 297
ASP A 277
ASN A 280
 None
 0.97A 3lslA-4pvcA:
undetectable
3lslD-4pvcA:
undetectable		 3lslA-4pvcA:
24.51
3lslD-4pvcA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 101
ILE A  98
ASN A 102
GLU A 182
 None
 1.05A 4a97E-4pvcA:
undetectable		 4a97E-4pvcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 101
ILE A  98
ASN A 102
GLU A 182
 None
 1.07A 4a97C-4pvcA:
undetectable		 4a97C-4pvcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 232
GLY A 298
THR A 300
LEU A 324
 None
 0.94A 4zdzA-4pvcA:
undetectable		 4zdzA-4pvcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 235
ILE A 232
GLY A 298
THR A 300
LEU A 324
 None
 1.08A 4ze2A-4pvcA:
undetectable		 4ze2A-4pvcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 330
ILE A 240
ASP A 241
ARG A 243
PHE A  11
 None
 1.39A 5nn8A-4pvcA:
undetectable		 5nn8A-4pvcA:
16.57