SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 LEU A 183
ALA A 217
SER A 125
GLY A 126
LEU A 106
None
None
FAD  A 601 (-3.4A)
None
FAD  A 601 (-4.8A)
1.00A 1fe2A-4pveA:
undetectable
1fe2A-4pveA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 LEU A 183
ALA A 217
SER A 125
GLY A 126
LEU A 106
None
None
FAD  A 601 (-3.4A)
None
FAD  A 601 (-4.8A)
1.10A 1igxA-4pveA:
undetectable
1igxA-4pveA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ALA A 410
GLY A 408
ARG A  94
GLU A 338
LEU A 414
None
None
None
NA  A 602 (-2.8A)
None
1.29A 1mjoC-4pveA:
undetectable
1mjoD-4pveA:
undetectable
1mjoC-4pveA:
12.73
1mjoD-4pveA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 VAL A 204
ILE A  79
LEU A 106
VAL A 104
ILE A  65
None
None
FAD  A 601 (-4.8A)
None
None
0.90A 1oipA-4pveA:
undetectable
1oipA-4pveA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
4 / 7 TYR A 486
ASP A 485
ASP A 482
HIS A 200
None
1.41A 1t03A-4pveA:
2.8
1t03A-4pveA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
4 / 7 MET A 196
LEU A 190
GLY A 188
ILE A  79
None
0.99A 2bdmA-4pveA:
undetectable
2bdmA-4pveA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
4 / 7 PHE A 487
VAL A 216
VAL A 104
VAL A  81
None
None
None
FAD  A 601 (-4.2A)
1.01A 2qbnA-4pveA:
undetectable
2qbnA-4pveA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ALA A 121
LEU A 222
PHE A 145
VAL A 155
GLY A 156
None
None
None
None
FAD  A 601 ( 3.6A)
1.04A 2ve3A-4pveA:
undetectable
2ve3A-4pveA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 TYR A 436
GLY A 208
TYR A  88
ALA A 203
LEU A 474
FAD  A 601 (-4.5A)
None
FAD  A 601 ( 3.7A)
None
None
1.17A 3vywA-4pveA:
undetectable
3vywA-4pveA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 TYR A 436
GLY A 208
TYR A  88
ALA A 203
LEU A 474
FAD  A 601 (-4.5A)
None
FAD  A 601 ( 3.7A)
None
None
1.10A 3vywB-4pveA:
undetectable
3vywB-4pveA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 TYR A 436
GLY A 208
TYR A  88
ALA A 203
LEU A 474
FAD  A 601 (-4.5A)
None
FAD  A 601 ( 3.7A)
None
None
1.16A 3vywC-4pveA:
undetectable
3vywC-4pveA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 9 ASN A 158
GLY A 162
GLY A 163
PHE A 164
GLY A 161
FAD  A 601 (-3.9A)
None
FAD  A 601 (-3.4A)
FAD  A 601 (-4.5A)
None
1.25A 3ztvA-4pveA:
undetectable
3ztvA-4pveA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 PHE A 159
GLY A 130
ALA A 121
VAL A 123
VAL A 112
None
1.03A 4nkxD-4pveA:
undetectable
4nkxD-4pveA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
3 / 3 ALA A 217
TRP A 122
VAL A 123
None
0.34A 4w9nC-4pveA:
undetectable
4w9nC-4pveA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ASP A 485
ASN A 447
ASP A 482
GLU A  99
GLU A 490
None
1.27A 5iqbA-4pveA:
undetectable
5iqbA-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
None
1.36A 5iqbA-4pveA:
undetectable
5iqbA-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 11 ASP A 485
ASN A 447
ASP A 482
GLU A  99
GLU A 490
None
1.27A 5iqbB-4pveA:
undetectable
5iqbB-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 11 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
None
1.36A 5iqbB-4pveA:
undetectable
5iqbB-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 11 ASP A 485
ASN A 447
ASP A 482
GLU A  99
GLU A 490
None
1.24A 5iqbC-4pveA:
undetectable
5iqbC-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 11 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
None
1.33A 5iqbC-4pveA:
undetectable
5iqbC-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ASP A 485
ASN A 447
ASP A 482
GLU A  99
GLU A 490
None
1.30A 5iqbD-4pveA:
undetectable
5iqbD-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
None
1.35A 5iqbD-4pveA:
undetectable
5iqbD-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ASP A 485
ASN A 447
ASP A 482
GLU A  99
GLU A 490
None
1.26A 5iqeC-4pveA:
undetectable
5iqeC-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
None
1.41A 5iqeC-4pveA:
undetectable
5iqeC-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 VAL A 204
ILE A  79
LEU A 106
VAL A 104
ILE A  65
None
None
FAD  A 601 (-4.8A)
None
None
0.90A 5mugA-4pveA:
undetectable
5mugA-4pveA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
4 / 4 ARG A 391
THR A 386
GLY A 162
PHE A 388
None
1.10A 5uunA-4pveA:
0.0
5uunA-4pveA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 12 GLY A 161
GLY A 157
SER A 492
ILE A 493
GLY A 207
None
FAD  A 601 (-3.1A)
None
None
None
0.82A 5zhmB-4pveA:
undetectable
5zhmB-4pveA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
5 / 9 ALA A 175
VAL A 204
ALA A 160
VAL A 181
GLY A 156
None
None
FAD  A 601 ( 4.5A)
None
FAD  A 601 ( 3.6A)
1.07A 6bklA-4pveA:
undetectable
6bklB-4pveA:
undetectable
6bklC-4pveA:
undetectable
6bklD-4pveA:
undetectable
6bklA-4pveA:
5.05
6bklB-4pveA:
5.05
6bklC-4pveA:
5.05
6bklD-4pveA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum
pratense)
4 / 7 ALA A 147
GLY A 148
TYR A 439
ASN A 158
None
FAD  A 601 (-3.3A)
FAD  A 601 ( 4.5A)
FAD  A 601 (-3.9A)
0.73A 6nm4A-4pveA:
undetectable
6nm4A-4pveA:
17.00