SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 7 SER A 404
TYR A 380
TRP A 371
GLN A 417
 None
 1.33A 1eiiA-4pvgA:
1.1		 1eiiA-4pvgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		3 / 3 ASP A 437
HIS A 520
ASP A 431
 None
 0.75A 1nw5A-4pvgA:
2.2		 1nw5A-4pvgA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 ARG A 512
VAL A 428
GLY A 427
TRP A 423
 None
 1.02A 2qd3A-4pvgA:
2.2		 2qd3A-4pvgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 6 PHE A 469
TRP A 423
GLY A 434
GLY A 433
 None
 0.90A 2qr2A-4pvgA:
undetectable
2qr2B-4pvgA:
undetectable		 2qr2A-4pvgA:
20.59
2qr2B-4pvgA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 5 TRP A 423
GLY A 434
GLY A 433
PHE A 469
 None
 0.93A 2qr2A-4pvgA:
undetectable
2qr2B-4pvgA:
undetectable		 2qr2A-4pvgA:
20.59
2qr2B-4pvgA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		3 / 3 ASN A 277
ASN A 306
ARG A 501
 None
 0.76A 2rlcA-4pvgA:
undetectable		 2rlcA-4pvgA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 5 VAL A 518
TYR A 515
VAL A 490
ASP A 489
 None
 1.25A 2x45C-4pvgA:
undetectable		 2x45C-4pvgA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 GLY A 464
GLY A 467
GLN A 506
VAL A 505
ILE A 514
 2WT  A 601 ( 3.9A)
None
2WT  A 601 (-3.4A)
None
None
 1.14A 3h52B-4pvgA:
undetectable		 3h52B-4pvgA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 ASP A 477
TYR A 521
GLY A 483
ILE A 479
 None
 0.91A 3ihzB-4pvgA:
undetectable		 3ihzB-4pvgA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 5 LEU A 525
HIS A 443
GLU A 440
HIS A 444
 None
 1.30A 4a7bB-4pvgA:
undetectable		 4a7bB-4pvgA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		3 / 3 MET A 496
GLN A 495
ARG A 498
 None
 1.12A 5ewzB-4pvgA:
undetectable		 5ewzB-4pvgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 11 TYR A 515
VAL A 471
ILE A 472
ILE A 479
ILE A 522
 None
 1.22A 5hw8E-4pvgA:
undetectable		 5hw8E-4pvgA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 6 PHE A 341
TRP A 342
ARG A 343
GLY A 381
 None
 1.12A 5o4yF-4pvgA:
undetectable		 5o4yF-4pvgA:
5.07