SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 ALA A 288
VAL A 290
TRP A  34
 None
 0.70A 1av2A-4pviA:
undetectable
1av2B-4pviA:
undetectable		 1av2A-4pviA:
3.27
1av2B-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 TRP A  34
ALA A 288
VAL A 290
 None
 0.76A 1av2C-4pviA:
undetectable
1av2D-4pviA:
undetectable		 1av2C-4pviA:
3.27
1av2D-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.23A 1p6kA-4pviA:
undetectable		 1p6kA-4pviA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.29A 1p6kB-4pviA:
undetectable		 1p6kB-4pviA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.27A 1rs6A-4pviA:
undetectable		 1rs6A-4pviA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.29A 1rs6B-4pviA:
undetectable		 1rs6B-4pviA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 ALA A 288
VAL A 290
TRP A  34
 None
 0.67A 1w5uA-4pviA:
undetectable
1w5uB-4pviA:
undetectable		 1w5uA-4pviA:
3.27
1w5uB-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 TRP A  34
ALA A 288
VAL A 290
 None
 0.74A 1w5uA-4pviA:
undetectable
1w5uB-4pviA:
undetectable		 1w5uA-4pviA:
3.27
1w5uB-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.23A 1zzqA-4pviA:
undetectable		 1zzqA-4pviA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.32A 1zzqB-4pviA:
undetectable		 1zzqB-4pviA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.19A 1zzuA-4pviA:
undetectable		 1zzuA-4pviA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.29A 1zzuB-4pviA:
undetectable		 1zzuB-4pviA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 SER A  70
TYR A  77
TYR A 338
HIS A 303
 None
None
2WS  A 601 (-4.1A)
None
 1.18A 2bteA-4pviA:
undetectable		 2bteA-4pviA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 THR A 146
PRO A 148
PRO A 102
 None
PO4  A 602 ( 4.5A)
None
 0.71A 2d55C-4pviA:
undetectable		 2d55C-4pviA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 PRO A 102
THR A 146
PRO A 148
 None
None
PO4  A 602 ( 4.5A)
 0.52A 2d55C-4pviA:
undetectable		 2d55C-4pviA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 ALA A 288
VAL A 290
TRP A  34
 None
 0.87A 2izqA-4pviA:
undetectable
2izqB-4pviA:
undetectable		 2izqA-4pviA:
3.27
2izqB-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 TRP A  34
ALA A 288
VAL A 290
 None
 0.72A 2izqC-4pviA:
undetectable
2izqD-4pviA:
undetectable		 2izqC-4pviA:
3.27
2izqD-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 7 ASP A 178
THR A 316
ILE A 237
ASN A  -6
 PO4  A 603 (-2.7A)
None
None
None
 1.28A 2jc9A-4pviA:
undetectable		 2jc9A-4pviA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 6 TRP A 229
TYR A 338
TYR A 226
ILE A 253
 2WS  A 601 (-4.0A)
2WS  A 601 (-4.1A)
2WS  A 601 (-4.9A)
None
 1.49A 2pgzD-4pviA:
undetectable
2pgzE-4pviA:
undetectable		 2pgzD-4pviA:
20.58
2pgzE-4pviA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 7 TYR A 168
TYR A 226
ASN A 339
LYS A  54
 2WS  A 601 (-4.0A)
2WS  A 601 (-4.9A)
2WS  A 601 (-2.8A)
None
 1.26A 2w98A-4pviA:
undetectable
2w98B-4pviA:
undetectable		 2w98A-4pviA:
19.74
2w98B-4pviA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 5 TYR A 199
ALA A 232
ALA A 131
MET A 212
 None
 1.09A 3d91A-4pviA:
undetectable		 3d91A-4pviA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 PRO A 142
TYR A 126
PRO A 111
GLY A 104
 None
 0.95A 3em0B-4pviA:
2.6		 3em0B-4pviA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 GLU A 230
GLU A 251
TRP A 343
 2WS  A 601 (-2.7A)
None
None
 1.26A 3hrdA-4pviA:
undetectable
3hrdE-4pviA:
undetectable
3hrdF-4pviA:
undetectable		 3hrdA-4pviA:
22.01
3hrdE-4pviA:
22.01
3hrdF-4pviA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 TRP A  34
ALA A 288
VAL A 290
 None
 0.94A 3l8lA-4pviA:
undetectable
3l8lB-4pviA:
undetectable		 3l8lA-4pviA:
3.27
3l8lB-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 TRP A  34
ALA A 288
VAL A 290
 None
 0.77A 3l8lC-4pviA:
undetectable
3l8lD-4pviA:
undetectable		 3l8lC-4pviA:
3.27
3l8lD-4pviA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.28A 3n62A-4pviA:
undetectable		 3n62A-4pviA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.29A 3n62B-4pviA:
undetectable		 3n62B-4pviA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.27A 3n66B-4pviA:
undetectable		 3n66B-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 7 ASN A 289
ALA A 285
ARG A 262
ALA A 277
 None
 1.13A 3twpB-4pviA:
undetectable		 3twpB-4pviA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 6 LEU A 121
PRO A 118
GLN A 313
TYR A 123
 None
 1.36A 3vkxA-4pviA:
undetectable		 3vkxA-4pviA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		5 / 12 ILE A 237
LEU A 319
ILE A 323
ILE A 234
LEU A 249
 None
 1.06A 3vrmA-4pviA:
undetectable		 3vrmA-4pviA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		5 / 12 SER A 300
PHE A 261
PRO A  56
GLN A 328
ILE A 348
 None
 1.39A 4b3aA-4pviA:
undetectable		 4b3aA-4pviA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		3 / 3 ARG A 200
TRP A 273
GLY A 271
 None
 1.02A 4e7cA-4pviA:
undetectable		 4e7cA-4pviA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 7 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.32A 4kcnB-4pviA:
undetectable		 4kcnB-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 6 VAL A 170
ASP A 171
SER A  70
PHE A 261
 None
 1.19A 4nedA-4pviA:
undetectable		 4nedA-4pviA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 5 LEU A 248
ASP A 221
GLU A 251
VAL A 170
 None
 1.15A 4nkvA-4pviA:
undetectable		 4nkvA-4pviA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		5 / 12 GLY A 346
THR A  37
ILE A 348
ILE A 307
PHE A  84
 None
 1.16A 4zvmA-4pviA:
undetectable
4zvmB-4pviA:
undetectable		 4zvmA-4pviA:
23.80
4zvmB-4pviA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		5 / 12 THR A  37
LEU A  40
PRO A  43
ILE A  50
VAL A 306
 None
 1.01A 5dlvB-4pviA:
undetectable		 5dlvB-4pviA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 5 ARG A 259
GLU A 251
ASP A  55
TRP A 343
 2WS  A 601 (-3.1A)
None
None
None
 1.41A 5kgjA-4pviA:
undetectable		 5kgjA-4pviA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 5 LEU A 205
CYH A 176
LEU A 315
ASP A 312
 None
 1.44A 5mafA-4pviA:
3.0		 5mafA-4pviA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.28A 5vunA-4pviA:
undetectable		 5vunA-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.31A 5vunB-4pviA:
undetectable		 5vunB-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.30A 5vuoB-4pviA:
undetectable		 5vuoB-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		4 / 8 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.32A 6auuB-4pviA:
undetectable		 6auuB-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4pvi GH62 HYDROLASE
(Mycothermus
thermophilus) 		5 / 10 PHE A 190
TYR A 123
TYR A 133
THR A 135
PHE A 114
 None
 1.49A 6hu9C-4pviA:
undetectable		 6hu9C-4pviA:
22.89