SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 11 LEU A  63
ILE A  93
ILE A  98
VAL A 103
PHE A  39
 None
 1.37A 1gx9A-4pw0A:
undetectable		 1gx9A-4pw0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 10 ILE A 219
ILE A 127
VAL A 103
GLY A 105
LEU A 242
 None
 1.15A 3elzC-4pw0A:
undetectable		 3elzC-4pw0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		3 / 3 GLN A  40
THR A  45
LEU A 178
 None
 0.74A 3ondA-4pw0A:
4.6		 3ondA-4pw0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		3 / 3 GLN A  40
THR A  45
LEU A 178
 None
 0.72A 3ondB-4pw0A:
3.9		 3ondB-4pw0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		4 / 6 ILE A 124
LEU A  63
ILE A  37
CYH A  38
 None
 0.92A 4asdA-4pw0A:
undetectable		 4asdA-4pw0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 ILE A  65
VAL A 270
ASP A  50
ILE A  53
GLU A 267
 None
 1.35A 4i41A-4pw0A:
undetectable		 4i41A-4pw0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		4 / 5 GLN A  40
THR A  45
LEU A 178
LEU A 181
 None
 1.10A 4lvcB-4pw0A:
undetectable		 4lvcB-4pw0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		4 / 6 ILE A 128
GLY A 105
ILE A  93
LEU A 277
 None
 0.59A 4o8fB-4pw0A:
undetectable		 4o8fB-4pw0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 LEU A 153
GLU A 157
LEU A 160
GLY A 260
HIS A 259
 None
None
None
None
CL  A 301 (-4.2A)
 1.13A 4pxmA-4pw0A:
undetectable		 4pxmA-4pw0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 11 LEU A 153
GLU A 157
LEU A 160
GLY A 260
HIS A 259
 None
None
None
None
CL  A 301 (-4.2A)
 1.16A 4pxmB-4pw0A:
undetectable		 4pxmB-4pw0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 10 ARG A 184
LEU A  63
ILE A  65
SER A  27
ALA A  11
 None
 1.05A 4z69I-4pw0A:
undetectable		 4z69I-4pw0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		4 / 4 GLN A  40
THR A  45
LEU A 178
LEU A 181
 None
 1.10A 5m5kB-4pw0A:
2.8		 5m5kB-4pw0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 LEU A 251
SER A 261
VAL A 130
GLY A 131
GLY A 228
 None
 1.14A 5nnaB-4pw0A:
1.1		 5nnaB-4pw0A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		4 / 5 LEU A  36
PHE A 101
LEU A 277
PHE A 276
 None
 1.21A 5x1fC-4pw0A:
undetectable
5x1fJ-4pw0A:
undetectable		 5x1fC-4pw0A:
23.38
5x1fJ-4pw0A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 ILE A  93
MET A 123
PHE A 101
THR A 273
LEU A 277
 None
 1.39A 6baaE-4pw0A:
undetectable		 6baaE-4pw0A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 ILE A  93
MET A 123
PHE A 101
THR A 273
LEU A 277
 None
 1.39A 6baaF-4pw0A:
undetectable		 6baaF-4pw0A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 ILE A  93
MET A 123
PHE A 101
THR A 273
LEU A 277
 None
 1.40A 6baaG-4pw0A:
undetectable		 6baaG-4pw0A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Chitinophaga
pinensis) 		5 / 12 ILE A  93
MET A 123
PHE A 101
THR A 273
LEU A 277
 None
 1.40A 6baaH-4pw0A:
undetectable		 6baaH-4pw0A:
10.31