SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 8 PHE A 143
TYR A 145
VAL A  87
GLY A  92
GLY A  93
 None
 1.21A 1ekjE-4pw1A:
undetectable
1ekjF-4pw1A:
undetectable		 1ekjE-4pw1A:
20.45
1ekjF-4pw1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 12 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
 None
 1.01A 1ynnC-4pw1A:
undetectable		 1ynnC-4pw1A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		3 / 3 ARG A 151
GLU A 152
THR A 154
 None
 0.80A 3v4tA-4pw1A:
undetectable		 3v4tA-4pw1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 12 GLN A 166
ASP A 168
LEU A  50
PRO A 273
ILE A 255
 None
 1.37A 4kmuH-4pw1A:
undetectable		 4kmuH-4pw1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 12 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
 None
 1.08A 4kmuH-4pw1A:
undetectable		 4kmuH-4pw1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 12 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
 None
 1.25A 5uacC-4pw1A:
undetectable		 5uacC-4pw1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 12 GLN A 148
ALA A 120
ARG A 277
VAL A  87
PHE A 143
 None
 1.21A 5vlmG-4pw1A:
undetectable		 5vlmG-4pw1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 4pw1 UNCHARACTERIZED
PROTEIN
([Clostridium]
leptum) 		5 / 12 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
 None
 1.18A 6ccvC-4pw1A:
undetectable		 6ccvC-4pw1A:
12.52